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Use of Hypervalent Iodine in the Synthesis of Isomeric Dihydrooxazoles

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Chemistry of Heterocyclic Compounds Aims and scope

A Correction to this article was published on 01 June 2018

This article has been updated

A convenient synthesis of 2- and/or 3-oxazolines has been developed depending on the structure and stereochemistry of the starting amino alcohol. PhI(OAc)2 acted as oxidant on the intermediate imine, as supported by NMR investigation. The findings demonstrate a new route providing access to unusual 3-oxazolines.

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Change history

  • 04 August 2018

    The name of author "Giuseppe Ronamazzi" should read "Giuseppe Romanazzi".

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We thank the University of Bari Aldo Moro, the Polytechnic of Bari, the project Laboratorio SISTEMA (Code PONa300369) financed by Italian Ministry of Education, Universities, and Research.

We are also grateful to Chiara Claudio and Valeria Decaro for their precious contribution.

Author information

Authors and Affiliations

  1. Flow Chemistry and Microreactor Technology Laboratory (FLAME-Lab), Department of Pharmacy – Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy

    Claudia Carlucci, Arianna Tota, Marco Colella, Renzo Luisi & Leonardo Degennaro

  2. DICATECh, Politecnico di Bari, Via E. Orabona 4, 70125, Bari, Italy

    Giuseppe Ronamazzi

  3. Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK

    Guy J. Clarkson

Authors
  1. Claudia Carlucci
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  2. Arianna Tota
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  3. Marco Colella
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  4. Giuseppe Ronamazzi
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  5. Guy J. Clarkson
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  6. Renzo Luisi
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  7. Leonardo Degennaro
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Corresponding authors

Correspondence to Claudia Carlucci or Renzo Luisi.

Additional information

Supplementary information file, containing NMR spectra, chiral HPLC data, and X-ray structural study parameters, is available at the journal website at http://link.springer.com/ journal/10593.

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(4), 428–436

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Carlucci, C., Tota, A., Colella, M. et al. Use of Hypervalent Iodine in the Synthesis of Isomeric Dihydrooxazoles. Chem Heterocycl Comp 54, 428–436 (2018). https://doi.org/10.1007/s10593-018-2288-9

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  • DOI: https://doi.org/10.1007/s10593-018-2288-9

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