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Tetrachlorosilane and zinc chloride as a binary reagent for the preparation of 2-amino-6-chloropyridine-3,5-dicarbonitrile derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

A green one-pot method for efficient synthesis of 2-amino-6-chloropyridine-3,5-dicarbonitrile derivatives was developed, based on stirring of various aldehydes and malononitrile with tetrachlorosilane and zinc chloride under solvent-free conditions at room temperature for 3–10 h. The effects of zinc chloride and the reaction conditions were studied. Compounds were characterized by X-ray analysis and NMR spectroscopy.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Mansoura University, El-Gamaa St, Mansoura, 35511, Egypt

    Saad S. Elmorsy

  2. Department of Chemistry, Faculty of Science, Damietta University, El-Kafrawy St, New Damietta, 34517, Egypt

    Ahmed M. Sheta, Mohammad M. A. Mashaly & Samy B. Said

Authors
  1. Saad S. Elmorsy
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  2. Ahmed M. Sheta
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  3. Mohammad M. A. Mashaly
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  4. Samy B. Said
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Correspondence to Ahmed M. Sheta.

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Supplementary information file containing the results of X-ray crystallographic analysis is available from the journal website at http://link.springer.com/journal/10593.

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2017, 53(5), 540–544

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Elmorsy, S.S., Sheta, A.M., Mashaly, M.M.A. et al. Tetrachlorosilane and zinc chloride as a binary reagent for the preparation of 2-amino-6-chloropyridine-3,5-dicarbonitrile derivatives. Chem Heterocycl Comp 53, 540–544 (2017). https://doi.org/10.1007/s10593-017-2089-6

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  • DOI: https://doi.org/10.1007/s10593-017-2089-6

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