Abstract
The brain is the most sensitive organ to hypoxia in the human body. Hypoxia in the brain will lead to damage to local brain tissue. When the blood supply of ischemic brain tissue is restored, the damage will worsen, that is, cerebral ischemia–reperfusion injury. Hydrogen sulfide (H2S) is a gaseous signal molecule and a novel endogenous neuroregulator. Indeed, different concentrations of H2S have different effects on neurons. Low concentration of H2S can play an important protective role in cerebral ischemia–reperfusion injury by inducing anti-oxidative stress injury, inhibition of inflammatory response, inhibition of cell apoptosis, reduction of cerebrovascular endothelial cell injury, regulation of autophagy, and other ways, which provides a new idea for clinical diagnosis and treatment of related diseases. This review aims to report the recent research progress on the dual effect of H2S on brain tissue during cerebral ischemia/reperfusion injury.
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This research was funded by the National Key Research and Development Program of China (2018YFA0108700, 2017YFA0105602), NSFC Projects of International Cooperation and Exchanges (81720108004), National Natural Science Foundation of China (81974019), The Research Team Project of Natural Science Foundation of Guangdong Province of China (2017A030312007), The key program of Guangzhou science research plan (201904020047), The Special Projects of Dengfeng Program of Guangdong Provincial People's Hospital (DFJH201812, KJ012019119 KJ012020630, KJ012019423), Natural Science Foundation of China (82001301), and the start-up Foundation of Guangdong Province (2018A030310113).
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Deng, G., Muqadas, M., Adlat, S. et al. Protective Effect of Hydrogen Sulfide on Cerebral Ischemia–Reperfusion Injury. Cell Mol Neurobiol 43, 15–25 (2023). https://doi.org/10.1007/s10571-021-01166-4
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DOI: https://doi.org/10.1007/s10571-021-01166-4