Abstract
The expression of H1 receptor has been reported in amacrine cells of mouse and rat retinae. However, we assumed that other types of histamine receptors also function in amacrine cells. In order to confirm that histamine modulates the membrane potential in mouse amacrine cells, we measured voltage-gated currents using whole-cell configuration. Under voltage-clamp conditions, the amplitude of voltage-gated outward currents was enhanced by the application of 100 µM histamine in 65% of amacrine cells. Histamine also increased the amplitudes of voltage-gated inward currents in 72% of amacrine cells. When antagonists of the histamine H1, H2, or H3 receptors were applied to histamine-sensitive amacrine cells, all three types of these inhibitors reduced the effect of histamine. Moreover, we classified recorded cells into seven types based on their morphological characteristics. Two of the seven types, diffuse multistratified cells and AII amacrine cells, responded significantly to histamine. These results indicate that histamine affected the membrane potential via three types of histamine receptors. Furthermore, there were differences in the responses to histamine among types of amacrine cells. Histamine may be one of the important neurotransmitters and/or neuromodulators in the visual processing.
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Acknowledgements
This work was supported by Ministry of Education, Culture, Sports, Science and Technology in Japan (SENRYAKU 1001034). We thank Dr. Fusao Kawai for advice.
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KH, MO, and EM designed the study; KH performed experiments; KH and MO analyzed data; KH, MO, and EM interpreted results of experiments; KH prepared figures; KH and MO wrote the initial draft of the manuscript; KH, MO, and EM approved the final version of the manuscript.
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All applicable international, national, and institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution. The article does not contain any studies with human participants.
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Horio, K., Ohkuma, M. & Miyachi, Ei. The Effect of Histamine on Inward and Outward Currents in Mouse Retinal Amacrine Cells. Cell Mol Neurobiol 38, 757–767 (2018). https://doi.org/10.1007/s10571-017-0542-9
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DOI: https://doi.org/10.1007/s10571-017-0542-9