Abstract
Recently, cellulose-based hydrogels have been widely used in biomedical applications. However, obtaining hydrogels with integrated tissue adhesion, sensing, haemostatic and wound healing capabilities remains challenging. In this study, we created a catechol-functionalised hydrogel based on multiple hydrogen bonds and π–π stacking using dopamine-modified dialdehyde carboxymethyl cellulose (DCMC-DA) and polyacrylic acid (PAA). The DCMC-DA/PAA hydrogel exhibited strong tissue adhesion, excellent biocompatibility, high sensing performance, effective haemostatic and wound-healing-inducive properties. The abundant aldehyde and catechol moieties of the hydrogels enhanced their adhesion to various substrates. The ions formed by catechol and carboxyl groups endowed the hydrogels with the ability to detect physiological activity signals. Furthermore, the hydrogel demonstrated haemostatic capability, reducing blood loss by 61.1% due to its remarkable adhesion and water absorption capacity. Based on this design strategy of excellent tissue adhesion and biocompatibility, the DCMC-DA/PAA hydrogel considerably accelerated wound healing by accelerating epithelial cell regeneration and collagen deposition. Hydrogels with tissue adhesion, sensing and haemostatic properties exhibit promise for wound healing.
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References
Asadi N, Pazoki-Toroudi H, Del Bakhshayesh AR, Akbarzadeh A, Davaran S, Annabi N (2021) Multifunctional hydrogels for wound healing: Special focus on biomacromolecular based hydrogels. Int J Biol Macromol 170:728–750. https://doi.org/10.1016/j.ijbiomac.2020.12.202
Bian S, Hao L, Qiu X, Wu J, Chang H, Kuang G-M, Zhang S, Hu X, Dai Y, Zhou Z, Huang F, Liu C, Zou X, Liu W, Lu WW, Pan H, Zhao X (2022) An Injectable Rapid-Adhesion and Anti-Swelling Adhesive Hydrogel for Hemostasis and Wound Sealing. Adv Funct Mater 32:2207741. https://doi.org/10.1002/adfm.202207741
Bian S, Chen Y, Huang X, Guo Y, Xiao H, Zhang M, Liu K, Huang L, Chen L, Wu H (2023) A catechol-containing dialdehyde cellulose adhesive with strong adhesion and biocompatibility. React Funct Polym 185:105542. https://doi.org/10.1016/j.reactfunctpolym.2023.105542
Bigi A, Cojazzi G, Panzavolta S, Rubini K, Roveri N (2001) Mechanical and thermal properties of gelatin films at different degrees of glutaraldehyde crosslinking. Biomaterials 22:763–768. https://doi.org/10.1016/S0142-9612(00)00236-2
Byun E, Ryu JH, Lee H (2014) Catalyst-mediated yet catalyst-free hydrogels formed by interfacial chemical activation. Chem Commun 50:2869–2872. https://doi.org/10.1039/C3CC49043B
Chen T, Chen Y, Rehman HU, Chen Z, Yang Z, Wang M, Li H, Liu H (2018) Ultratough, self-healing, and tissue-adhesive hydrogel for wound dressing. ACS Appl Mater 10:33523–33531. https://doi.org/10.1021/acsami.8b10064
Chen X, Yuk H, Wu J, Nabzdyk CS, Zhao X (2020) Instant tough bioadhesive with triggerable benign detachment. Proc Natl Acad Sci USA 117:15497–15503. https://doi.org/10.1073/pnas.2006389117
Cui C, Liu W (2021) Recent advances in wet adhesives: Adhesion mechanism, design principle and applications. Prog Polym Sci 116:101388. https://doi.org/10.1016/j.progpolymsci.2021.101388
Cui L, Li J, Guan S, Zhang K, Zhang K, Li J (2022) Injectable multifunctional CMC/HA-DA hydrogel for repairing skin injury. Materials Today Bio 14:100257. https://doi.org/10.1016/j.mtbio.2022.100257
Ding X, Li G, Zhang P, Jin E, Xiao C, Chen X (2021) Injectable self-healing hydrogel wound dressing with cysteine-specific on-demand dissolution property based on tandem dynamic covalent bonds. Adv Funct Mater 31:2011230. https://doi.org/10.1002/adfm.202011230
Farhadnejad H, Mortazavi SA, Erfan M, Darbasizadeh B, Motasadizadeh H, Fatahi Y (2018) Facile preparation and characterization of pH sensitive Mt/CMC nanocomposite hydrogel beads for propranolol controlled release. Int J Biol Macromol 111:696–705. https://doi.org/10.1016/j.ijbiomac.2018.01.061
Fu L-H, Qi C, Ma M-G, Wan P (2019) Multifunctional cellulose-based hydrogels for biomedical applications. J Mater Chem B 7:1541–1562. https://doi.org/10.1039/C8TB02331J
Gan D, Xu T, Xing W, Ge X, Fang L, Wang K, Ren F, Lu X (2019) Mussel-Inspired Contact-Active Antibacterial Hydrogel with High Cell Affinity, Toughness, and Recoverability. Adv Funct Mater 29:1805964. https://doi.org/10.1002/adfm.201805964
Gong C, Wu Q, Wang Y, Zhang D, Luo F, Zhao X, Wei Y, Qian Z (2013) A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing. Biomaterials 34:6377–6387. https://doi.org/10.1016/j.biomaterials.2013.05.005
Gristina AG (1987) Biomaterial-centered infection: microbial adhesion versus tissue integration. Science 237:1588–1595. https://doi.org/10.1126/science.3629258
Guo T, Gu L, Zhang Y, Chen H, Jiang B, Zhao H, Jin Y, Xiao H (2019) Bioinspired self-assembled films of carboxymethyl cellulose–dopamine/montmorillonite. J Mater Chem A 7:14033–14041. https://doi.org/10.1039/C9TA00998A
Guo H, Bai M, Zhu Y, Liu X, Tian S, Long Y, Ma Y, Wen C, Li Q, Yang J, Zhang L (2021a) Pro-healing zwitterionic skin sensor enables multi-indicator distinction and continuous real-time monitoring. Adv Funct Mater 31:2106406. https://doi.org/10.1002/adfm.202106406
Guo T, Wang W, Song J, Jin Y, Xiao H (2021b) Dual-responsive carboxymethyl cellulose/dopamine/cystamine hydrogels driven by dynamic metal-ligand and redox linkages for controllable release of agrochemical. Carbohydr Polym 253:117188. https://doi.org/10.1016/j.carbpol.2020.117188
Han L, Yan L, Wang K, Fang L, Zhang H, Tang Y, Ding Y, Weng L-T, Xu J, Weng J, Liu Y, Ren F, Lu X (2017) Tough, self-healable and tissue-adhesive hydrogel with tunable multifunctionality. NPG Asia Mater 9:e372. https://doi.org/10.1038/am.2017.33
He J, Shi M, Liang Y, Guo B (2020) Conductive adhesive self-healing nanocomposite hydrogel wound dressing for photothermal therapy of infected full-thickness skin wounds. Chem Eng J 394:124888. https://doi.org/10.1016/j.cej.2020.124888
Huang Y, Zhao X, Zhang Z, Liang Y, Yin Z, Chen B, Bai L, Han Y, Guo B (2020) Degradable gelatin-based IPN cryogel hemostat for rapidly stopping deep noncompressible hemorrhage and simultaneously improving wound healing. Chem Mater 32:6595–6610. https://doi.org/10.1021/acs.chemmater.0c02030
Huang X, Fu Q, Deng Y, Wang F, Xia B, Chen Z, Chen G (2021) Surface roughness of silk fibroin/alginate microspheres for rapid hemostasis in vitro and in vivo. Carbohyd Polym 253:117256. https://doi.org/10.1016/j.carbpol.2020.117256
Kloth LC (2014) Electrical stimulation technologies for wound healing. Adv Wound Care (new Rochelle) 3:81–90. https://doi.org/10.1089/wound.2013.0459
Kong W, Yue Q, Li Q, Gao B (2019) Adsorption of Cd2+ on GO/PAA hydrogel and preliminary recycle to GO/PAA-CdS as efficient photocatalyst. Sci Total Environ 668:1165–1174. https://doi.org/10.1016/j.scitotenv.2019.03.095
Li H, Wu B, Mu C, Lin W (2011) Concomitant degradation in periodate oxidation of carboxymethyl cellulose. Carbohydr Polym 84:881–886. https://doi.org/10.1016/j.carbpol.2010.12.026
Li M, Zhang Z, Liang Y, He J, Guo B (2020a) Multifunctional tissue-adhesive cryogel wound dressing for rapid nonpressing surface hemorrhage and wound repair. ACS Appl Mater 12:35856–35872. https://doi.org/10.1021/acsami.0c08285
Li S, Wang L, Zheng W, Yang G, Jiang X (2020b) Rapid fabrication of self-healing, conductive, and injectable gel as dressings for healing wounds in stretchable parts of the body. Adv Funct Mater 30:2002370. https://doi.org/10.1002/adfm.202002370
Li N, Wanyan H, Lu S, Xiao H, Zhang M, Liu K, Li X, Du B, Huang L, Chen L, Ni Y, Wu H (2023) Robust cellulose-based hydrogel marbles with excellent stability for gas sensing. Carbohydr Polym 306:120617. https://doi.org/10.1016/j.carbpol.2023.120617
Liang Y, Li Z, Huang Y, Yu R, Guo B (2021) Dual-dynamic-bond cross-linked antibacterial adhesive hydrogel sealants with on-demand removability for post-wound-closure and infected wound healing. ACS Nano 15:7078–7093. https://doi.org/10.1021/acsnano.1c00204
Liu C, Liu C, Yu S, Wang N, Yao W, Liu X, Sun G, Song Q, Qiao W (2020) Efficient antibacterial dextran-montmorillonite composite sponge for rapid hemostasis with wound healing. Int J Biol Macromol 160:1130–1143. https://doi.org/10.1016/j.ijbiomac.2020.05.140
Lou D, Luo Y, Pang Q, Tan W-Q, Ma L (2020) Gene-activated dermal equivalents to accelerate healing of diabetic chronic wounds by regulating inflammation and promoting angiogenesis. Bioact Mater 5:667–679. https://doi.org/10.1016/j.bioactmat.2020.04.018
Lu J, Han X, Dai L, Li C, Wang J, Zhong Y, Yu F, Si C (2020) Conductive cellulose nanofibrils-reinforced hydrogels with synergetic strength, toughness, self-adhesion, flexibility and adjustable strain responsiveness. Carbohydr Polym 250:117010. https://doi.org/10.1016/j.carbpol.2020.117010
Lu S, Zhang X, Tang Z, Xiao H, Zhang M, Liu K, Chen L, Huang L, Ni Y, Wu H (2021) Mussel-inspired blue-light-activated cellulose-based adhesive hydrogel with fast gelation, rapid haemostasis and antibacterial property for wound healing. Chem Eng J 417:129329. https://doi.org/10.1016/j.cej.2021.129329
Lu Y, Yue Y, Ding Q, Mei C, Xu X, Jiang S, He S, Wu Q, Xiao H, Han J (2023) Environment-tolerant ionic hydrogel–elastomer hybrids with robust interfaces, high transparence, and biocompatibility for a mechanical–thermal multimode sensor. InfoMat 5:e12409. https://doi.org/10.1002/inf2.12409
Mallakpour S, Tukhani M, Hussain CM (2021) Recent advancements in 3D bioprinting technology of carboxymethyl cellulose-based hydrogels: utilization in tissue engineering. Adv Colloid Interface Sci 292:102415. https://doi.org/10.1016/j.cis.2021.102415
Miao Y, Tang Z, Zhang Q, Reheman A, Xiao H, Zhang M, Liu K, Huang L, Chen L, Wu H (2022) Biocompatible lignin-containing hydrogels with self-adhesion, conductivity, UV shielding, and antioxidant activity as wearable sensors. ACS Appl Polym Mater 4:1448–1456. https://doi.org/10.1021/acsapm.1c01817
Montazerian H, Davoodi E, Baidya A, Baghdasarian S, Sarikhani E, Meyer CE, Haghniaz R, Badv M, Annabi N, Khademhosseini A, Weiss PS (2022) Engineered hemostatic biomaterials for sealing wounds. Chem Rev 122:12864–12903. https://doi.org/10.1021/acs.chemrev.1c01015
Muir VG, Burdick JA (2021) Chemically modified biopolymers for the formation of biomedical hydrogels. Chem Rev 121:10908–10949. https://doi.org/10.1021/acs.chemrev.0c00923
Pan M, Nguyen K-CT, Yang W, Liu X, Chen X-Z, Major PW, Le LH, Zeng H (2022) Soft armour-like layer-protected hydrogels for wet tissue adhesion and biological imaging. Chem Eng J 434:134418. https://doi.org/10.1016/j.cej.2021.134418
Pandit AH, Mazumdar N, Ahmad S (2019) Periodate oxidized hyaluronic acid-based hydrogel scaffolds for tissue engineering applications. Int J Biol Macromol 137:853–869. https://doi.org/10.1016/j.ijbiomac.2019.07.014
Sharma AK, Priya KBS, Bhagya S, Simran S (2021) Borax mediated synthesis of a biocompatible self-healing hydrogel using dialdehyde carboxymethyl cellulose-dextrin and gelatin. React Funct Polym 166:104977. https://doi.org/10.1016/j.reactfunctpolym.2021.104977
Shin J, Choi S, Kim JH, Cho JH, Jin Y, Kim S, Min S, Kim SK, Choi D, Cho S-W (2019) Tissue tapes—phenolic hyaluronic acid hydrogel patches for off-the-shelf therapy. Adv Funct Mater 29:1903863. https://doi.org/10.1002/adfm.201903863
Suneetha M, Rao KM, Han SS (2019) Mussel-inspired cell/tissue-adhesive, hemostatic hydrogels for tissue engineering applications. ACS Omega 4:12647–12656. https://doi.org/10.1021/acsomega.9b01302
Suneetha M, Moo SO, Choi SM, Zo S, Rao MK, Han SS (2021) Tissue-adhesive, stretchable, and self-healable hydrogels based on carboxymethyl cellulose-dopamine/PEDOT:PSS via mussel-inspired chemistry for bioelectronic applications. Chem Eng J 426:130847. https://doi.org/10.1016/j.cej.2021.130847
Suneetha M, Rao KM, Han SS (2022) Cell/tissue adhesive, self-healable, biocompatible, hemostasis, and antibacterial hydrogel dressings for wound healing applications. Adv Mater Interfaces 9:2102369. https://doi.org/10.1002/admi.202102369
Suneetha M, Zo S, Choi SM, Han SS (2023) Antibacterial, biocompatible, hemostatic, and tissue adhesive hydrogels based on fungal-derived carboxymethyl chitosan-reduced graphene oxide-polydopamine for wound healing applications. Int J Biol Macromol 241:124641. https://doi.org/10.1016/j.ijbiomac.2023.124641
Tang P, Han L, Li P, Jia Z, Wang K, Zhang H, Tan H, Guo T, Lu X (2019) Mussel-inspired electroactive and antioxidative scaffolds with incorporation of polydopamine-reduced graphene oxide for enhancing skin wound healing. ACS Appl Mater Interfaces 11:7703–7714. https://doi.org/10.1021/acsami.8b18931
Tang Z, Miao Y, Zhao J, Xiao H, Zhang M, Liu K, Zhang X, Huang L, Chen L, Wu H (2021) Mussel-inspired biocompatible polydopamine/carboxymethyl cellulose/polyacrylic acid adhesive hydrogels with UV-shielding capacity. Cellulose 28:1527–1540. https://doi.org/10.1007/s10570-020-03596-7
Tang L, Dang Y, Wang Y, Zhang Y, Hu T, Ding C, Wu H, Ni Y, Chen L, Huang L, Zhang M (2022) Rapid fabrication of bionic pyrogallol-based self-adhesive hydrogel with mechanically tunable, self-healing, antibacterial, wound healing, and hemostatic properties. Biomater Adv 136:212765. https://doi.org/10.1016/j.bioadv.2022.212765
Tu H, Zhu M, Duan B, Zhang L (2021) Recent progress in high-strength and robust regenerated cellulose materials. Adv Mater 33:2000682. https://doi.org/10.1002/adma.202000682
Wang T, Liu D, Lian C, Zheng S, Liu X, Tong Z (2012) Large deformation behavior and effective network chain density of swollen poly(N-isopropylacrylamide)–Laponite nanocomposite hydrogels. Soft Matter 8:774–783. https://doi.org/10.1039/c1sm06484c
Wang P, He H, Cai R, Tao G, Yang M, Zuo H, Umar A, Wang Y (2019) Cross-linking of dialdehyde carboxymethyl cellulose with silk sericin to reinforce sericin film for potential biomedical application. Carbohydr Polym 212:403–411. https://doi.org/10.1016/j.carbpol.2019.02.069
Wang Z, Cong Y, Fu J (2020) Stretchable and tough conductive hydrogels for flexible pressure and strain sensors. J Mater Chem B 8:3437–3459. https://doi.org/10.1039/c9tb02570g
Wang C, Zhu M, Yu HY, Abdalkarim SYH, Ouyang Z, Zhu J, Yao J (2021) Multifunctional biosensors made with self-healable silk fibroin imitating skin. ACS Appl Mater 13:33371–33382. https://doi.org/10.1021/acsami.1c08568
Wang Y, He C, Chen C, Dong W, Yang X, Wu Y, Kong Q, Yan B (2022) Thermoresponsive self-healing zwitterionic hydrogel as an in situ gelling wound dressing for rapid wound healing. ACS Appl Mater 14:55342–55353. https://doi.org/10.1021/acsami.2c15820
Wang Y, Luo M, Li T, Xie C, Li S, Lei B (2023) Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair. Bioact Mater 25:319–332. https://doi.org/10.1016/j.bioactmat.2023.01.019
Wang H, Yi X, Liu T, Liu J, Wu Q, Ding Y, Liu Z, Wang Q (2023a) An Integrally formed Janus hydrogel for robust wet-tissue adhesive and anti-postoperative adhesion. Adv Mater 35:2300394. https://doi.org/10.1002/adma.202300394
Wang Z, Wei H, Huang Y, Wei Y, Chen J (2023b) Naturally sourced hydrogels: emerging fundamental materials for next-generation healthcare sensing. Chem Soc Rev 52:2992–3034. https://doi.org/10.1039/D2CS00813K
White JD, Wilker JJ (2011) Underwater bonding with charged polymer mimics of marine mussel adhesive proteins. Macromolecules 44:5085–5088. https://doi.org/10.1021/ma201044x
Wu X, Han Y, Zhang X, Zhou Z, Lu C (2016) Large-area compliant, low-cost, and versatile pressure-sensing platform based on microcrack-designed carbon black@polyurethane sponge for human-machine Interfacing. Adv Funct Mater 26:6246–6256. https://doi.org/10.1002/adfm.201601995
Wu T, Cui C, Huang Y, Liu Y, Fan C, Han X, Yang Y, Xu Z, Liu B, Fan G, Liu W (2020) Coadministration of an adhesive conductive hydrogel patch and an injectable hydrogel to treat myocardial infarction. ACS Appl Mater 12:2039–2048. https://doi.org/10.1021/acsami.9b17907
Wu L, Hu Y, Tang P, Wang H, Bin Y (2021) High stretchable, pH-sensitive and self-adhesive rGO/CMCNa/PAA composite conductive hydrogel with good strain-sensing performance. Compos Commun 24:100669. https://doi.org/10.1016/j.coco.2021.100669
Xu H, Fang Z, Tian W, Wang Y, Ye Q, Zhang L, Cai J (2018) Green Fabrication of amphiphilic quaternized β-chitin derivatives with excellent biocompatibility and antibacterial activities for wound healing. Adv Mater 30:1801100. https://doi.org/10.1002/adma.201801100
Xu H, Zhang L, Cai J (2019) Injectable, self-healing, β-chitin-based hydrogels with excellent cytocompatibility, antibacterial activity, and potential as drug/cell carriers. ACS Appl Bio Mater 2:196–204. https://doi.org/10.1021/acsabm.8b00548
Yang Q, Tang L, Guo C, Deng F, Wu H, Chen L, Huang L, Lu P, Ding C, Ni Y, Zhang M (2021a) A bioinspired gallol-functionalized collagen as wet-tissue adhesive for biomedical applications. Chem Eng J 417:127962. https://doi.org/10.1016/j.cej.2020.127962
Yang Y, Lu Y-T, Zeng K, Heinze T, Groth T, Zhang K (2021b) Recent progress on cellulose-based ionic compounds for biomaterials. Adv Mater 33:2000717. https://doi.org/10.1002/adma.202000717
Yang W, Kang X, Gao X, Zhuang Y, Fan C, Shen H, Chen Y, Dai J (2023) Biomimetic natural biopolymer-based wet-tissue adhesive for tough adhesion, seamless sealed, emergency/nonpressing hemostasis, and promoted wound healing. Adv Funct Mater 33:2211340. https://doi.org/10.1002/adfm.202211340
Ye Y, Zhang Y, Chen Y, Han X, Jiang F (2020) Cellulose nanofibrils enhanced, strong, stretchable, freezing-tolerant ionic conductive organohydrogel for multi-functional sensors. Adv Funct Mater 30:2003430. https://doi.org/10.1002/adfm.202003430
Yi Y, Jiang Z, Yang S, Ding W, Wang Y-n, Shi B (2020) Formaldehyde formation during the preparation of dialdehyde carboxymethyl cellulose tanning agent. Carbohydr Polym 239:116217. https://doi.org/10.1016/j.carbpol.2020.116217
Yuk H, Lu B, Zhao X (2019) Hydrogel bioelectronics. Chem Soc Rev 48:1642–1667. https://doi.org/10.1039/C8CS00595H
Zhang L, Ma Y, Pan X, Chen S, Zhuang H, Wang S (2018) A composite hydrogel of chitosan/heparin/poly (gamma-glutamic acid) loaded with superoxide dismutase for wound healing. Carbohydr Polym 180:168–174. https://doi.org/10.1016/j.carbpol.2017.10.036
Zhang R, Peng H, Zhou T, Yao Y, Zhu X, Bi B, Zhang X, Liu B, Niu L, Wang W (2019) Constructing high performance hydrogels with strong underwater adhesion through a “mussel feet-rock” inspired strategy. ACS Appl Polym Mater 1:2883–2889. https://doi.org/10.1021/acsapm.9b00590
Zhang C, Wu B, Zhou Y, Zhou F, Liu W, Wang Z (2020a) Mussel-inspired hydrogels: from design principles to promising applications. Chem Soc Rev 49:3605–3637. https://doi.org/10.1039/C9CS00849G
Zhang W, Wang R, Sun Z, Zhu X, Zhao Q, Zhang T, Cholewinski A, Yang F, Zhao B, Pinnaratip R, Forooshani PK, Lee BP (2020b) Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications. Chem Soc Rev 49:433–464. https://doi.org/10.1039/C9CS00285E
Zhang M, Qiao X, Han W, Jiang T, Liu F, Zhao X (2021a) Alginate-chitosan oligosaccharide-ZnO composite hydrogel for accelerating wound healing. Carbohydr Polym 266:118100. https://doi.org/10.1016/j.carbpol.2021.118100
Zhang X, Wei J, Lu S, Xiao H, Miao Q, Zhang M, Liu K, Chen L, Huang L, Wu H (2021b) Mussel-inspired conductive hydrogel with self-healing, adhesive, and antibacterial properties for wearable monitoring. ACS Appl Polym Mater 3:5798–5807. https://doi.org/10.1021/acsapm.1c01026
Zhang M, Yang Q, Hu T, Tang L, Ni Y, Chen L, Wu H, Huang L, Ding C (2022) Adhesive, antibacterial, conductive, anti-uv, self-healing, and tough collagen-based hydrogels from a pyrogallol-ag self-catalysis system. ACS Appl Mater 14:8728–8742. https://doi.org/10.1021/acsami.1c21200
Zhang Z, Wang C, Li F, Liang L, Huang L, Chen L, Ni Y, Gao P, Wu H (2023) Bifunctional cellulose interlayer enabled efficient perovskite solar cells with simultaneously enhanced efficiency and stability. Adv Sci 10:2207202. https://doi.org/10.1002/advs.202207202
Zhao X, Sun X, Yildirimer L, Lang Q, Lin ZYW, Zheng R, Zhang Y, Cui W, Annabi N, Khademhosseini A (2017) Cell infiltrative hydrogel fibrous scaffolds for accelerated wound healing. Acta Biomater 49:66–77. https://doi.org/10.1016/j.actbio.2016.11.017
Zhao X, Guo B, Wu H, Liang Y, Ma PX (2018) Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing. Nat Commun 9:2784. https://doi.org/10.1038/s41467-018-04998-9
Zhu J, Li F, Wang X, Yu J, Wu D (2018) Hyaluronic acid and polyethylene glycol hybrid hydrogel encapsulating nanogel with hemostasis and sustainable antibacterial property for wound healing. ACS Appl Mater 10:13304–13316. https://doi.org/10.1021/acsami.7b18927
Zhu T, Cheng Y, Cao C, Mao J, Li L, Huang J, Gao S, Dong X, Chen Z, Lai Y (2020) A semi-interpenetrating network ionic hydrogel for strain sensing with high sensitivity, large strain range, and stable cycle performance. Chem Eng J 385:123912. https://doi.org/10.1016/j.cej.2019.123912
Zhu Z, Zhang K, Xian Y, He G, Pan Z, Wang H, Zhang C, Wu D (2023) A choline phosphoryl-conjugated chitosan/oxidized dextran injectable self-healing hydrogel for improved hemostatic efficacy. Biomacromol 24:690–703. https://doi.org/10.1021/acs.biomac.2c01143
Zong S, Wen H, Lv H, Li T, Tang R, Liu L, Jiang J, Wang S, Duan J (2022) Intelligent hydrogel with both redox and thermo-response based on cellulose nanofiber for controlled drug delivery. Carbohydr Polym 278:118943. https://doi.org/10.1016/j.carbpol.2021.118943
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This work was supported by the National Natural Science Foundation of China (22278071), and the China Postdoctoral Science Foundation (2022M721038).
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SL: Experimental methods, Investigation, Data analysis, Writing original draft. SB: Experimental methods, Data analysis, Validation. YJ: Experimental methods, Investigation. YG: Experimental methods, Validation. HX: Formal analysis, Validation. MZ: Experimental methods, Validation. KL: Experimental methods, Validation. LH: Project administration, Validation. LC: Project administration, Validation. YN: Validation. HW: Conceptualization, Supervision, Writing-review & editing.
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Lu, S., Bian, S., Jia, Y. et al. Catechol-functionalised dialdehyde cellulose-containing hydrogels with tissue adhesion, sensing and haemostatic properties for wound healing. Cellulose 31, 2355–2377 (2024). https://doi.org/10.1007/s10570-024-05762-7
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DOI: https://doi.org/10.1007/s10570-024-05762-7