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Fabrication of β cyclodextrin containing AIE-active polymeric composites through formation of dynamic phenylboronic borate and their theranostic applications

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Abstract

Since the first discovery by Tang in 2001, aggregation-induced emission (AIE) phenomenon has attracted considerable research interest in various fields. In this contribution, AIE-active composites (named as An-HPG-β-CD) have been fabricated via conjugation of AIE-active compound An-B(OH)2 and hyperbranched polyglycerol functionalized β cyclodextrin (HPG-β-CD) based on dynamic phenyl borate for the first time. The potential biomedical applications of these AIE-active composites for biological imaging and drug delivery applications were further explored. The successful preparation of An-HPG-β-CD composites was confirmed through a series of characterization techniques. The An-HPG-β-CD composites possess great water dispersibility, low cytotoxicity, excellent fluorescence properties and uniform size and morphology, which make them promising for cell imaging. Furthermore, the cavities of An-HPG-β-CD composites could be utilized for loading with doxorubicin for drug delivery applications. In conclusion, we have developed a novel method for fabrication of AIE-active An-HPG-β-CD composites through formation of dynamic phenylboronic borate between β cyclodextrin containing hyperbranched polyglycerol and phenylboronic containing AIE dye. These AIE-active composites are of great potential in biological imaging and drug delivery applications.

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Acknowledgments

This research was supported by the National Natural Science Foundation of China (Nos. 21788102, 21865016, 51363016, 21474057, 21564006, 21561022, 21644014).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Nanchang University, Nanchang, 330031, Jiangxi, China

    Hongye Huang & Naigen Zhou

  2. Department of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031, China

    Hongye Huang, Meiying Liu, Junyu Chen, Liucheng Mao, Qing Wan, Yuanqing Wen, Fengjie Deng & Xiaoyong Zhang

  3. Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing, 100084, People’s Republic of China

    Yen Wei

  4. Department of Chemistry and Center for Nanotechnology and Institute of Biomedical Technology, Chung-Yuan Christian University, Chung-Li, 32023, Taiwan

    Yen Wei

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  1. Hongye Huang
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Correspondence to Naigen Zhou, Xiaoyong Zhang or Yen Wei.

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Huang, H., Liu, M., Chen, J. et al. Fabrication of β cyclodextrin containing AIE-active polymeric composites through formation of dynamic phenylboronic borate and their theranostic applications. Cellulose 26, 8829–8841 (2019). https://doi.org/10.1007/s10570-019-02674-9

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