Abstract
The development of paper-based analytical platforms has brought a requirement on easily creating patterned paper sensors. This article describes a facile method of fabricating patterned paper sensors using a combination of wettability-controlled paper and the precipitation assays between analytes and sensing elements. Different from common fabrication processes in which patterned channels are defined by creating hydrophobic barriers, herein the direct deposition of the patterns of sensing elements onto paper is performed by simple writing and stamping. Without hydrophobic treatment, the patterned sensing components can remain in place on the paper substrate whose wettability is tuned via bovine serum albumin (BSA) modification. After exposure to the analytes, the precipitates of sensing reactions are not delocalized, giving a simple and successful patterned signal readout. The results of typical colorimetric assays show that slow capillary flow and insoluble products together on paper provide an extremely easy route for fabricating multifunctional patterned paper sensors.
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References
Ahmed S, Bui MPN, Abbas A (2016) Paper-based chemical and biological sensors: engineering aspects. Biosens Bioelectron 77:249–263
Bănică FG (2012) Chemical sensors and biosensors: fundamentals and applications. Wiley, Hoboken
Carrasquilla C, Little JRL, Li Y, Brennan JD (2015) Patterned paper sensors printed with long-chain DNA aptamers. Chem Eur J 21:7369–7373
Cate DM, Dungchai W, Cunningham JC, Volckens J, Henry CS (2013) Simple, distance-based measurement for paper analytical devices. Lab Chip 13:2397–2404
Cate DM, Noblitt SD, Volckens J, Henry CS (2015) Multiplexed paper analytical device for quantification of metals using distance-based detection. Lab Chip 15:2808–2818
Cheng CM, Martinez AW, Gong J, Mace CR, Phillips ST, Carrilho E, Mirica KA, Whitesides GM (2010) Paper-based ELISA. Angew Chem Int Ed 49:4771–4774
Garcia PT, Cardoso TMG, Garcia CD, Carrilho E, Coltro WKT (2014) A handheld stamping process to fabricate microfluidic paper-based analytical devices with chemically modified surface for clinical assays. RSC Adv 4:37637–37644
Gehring A, He X, Fratamico P, Lee J, Bagi L, Brewster J, Paoli G, He Y, Xie Y, Skinner C, Barnett C, Harris D (2014) A high-throughput, precipitating colorimetric sandwich ELISA microarray for Shiga toxins. Toxins 6:1855
He Q, Ma C, Hu X, Chen H (2013) Method for fabrication of paper-based microfluidic devices by alkylsilane self-assembling and UV/O3-patterning. Anal Chem 85:1327–1331
Hubbe MA (2007) Paper’s resistance to wetting—a review of internal sizing chemicals and their effects. BioResources 2:106–145
Jeong SG, Lee SH, Choi CH, Kim J, Lee CS (2015) Toward instrument-free digital measurements: a three-dimensional microfluidic device fabricated in a single sheet of paper by double-sided printing and lamination. Lab Chip 15:1188–1194
Li M, Tian J, Al-Tamimi M, Shen W (2012) Paper-based blood typing device that reports patient’s blood type “in writing”. Angew Chem Int Ed 51:5497–5501
Liana DD, Raguse B, Gooding JJ, Chow E (2012) Recent advances in paper-based sensors. Sensors 12:11505
Määttänen A, Fors D, Wang S, Valtakari D, Ihalainen P, Peltonen J (2011) Paper-based planar reaction arrays for printed diagnostics. Sens Actuators, B 160:1404–1412
Maejima K, Tomikawa S, Suzuki K, Citterio D (2013) Inkjet printing: an integrated and green chemical approach to microfluidic paper-based analytical devices. RSC Adv 3:9258–9263
Martinez AW, Phillips ST, Butte MJ, Whitesides GM (2007) Patterned paper as a platform for inexpensive, low-volume, portable bioassays. Angew Chem Int Ed 46:1318–1320
Meredith NA, Quinn C, Cate DM, Reilly TH, Volckens J, Henry CS (2016) Paper-based analytical devices for environmental analysis. Analyst 141:1874–1887
Murdock RC, Shen L, Griffin DK, Kelley-Loughnane N, Papautsky I, Hagen JA (2013) Optimization of a paper-based ELISA for a human performance biomarker. Anal Chem 85:11634–11642
Nurak T, Praphairaksit N, Chailapakul O (2013) Fabrication of paper-based devices by lacquer spraying method for the determination of nickel(II) ion in waste water. Talanta 114:291–296
OuYang L, Wang C, Du F, Zheng T, Liang H (2014) Electrochromatographic separations of multi-component metal complexes on a microfluidic paper-based device with a simplified photolithography. RSC Adv 4:1093–1101
Oyola-Reynoso S, Heim AP, Halbertsma-Black J, Zhao C, Tevis ID, Çınar S, Cademartiri R, Liu X, Bloch JF, Thuo MM (2015) Draw your assay: fabrication of low-cost paper-based diagnostic and multi-well test zones by drawing on a paper. Talanta 144:289–293
Pelton R (2009) Bioactive paper provides a low-cost platform for diagnostics. Trends Anal Chem 28:925–942
Sameenoi Y, Nongkai PN, Nouanthavong S, Henry CS, Nacapricha D (2014) One-step polymer screen-printing for microfluidic paper-based analytical device (µPAD) fabrication. Analyst 139:6580–6588
Samyn P (2013) Wetting and hydrophobic modification of cellulose surfaces for paper applications. J Mater Sci 48:6455–6498
Songjaroen T, Dungchai W, Chailapakul O, Laiwattanapaisal W (2011) Novel, simple and low-cost alternative method for fabrication of paper-based microfluidics by wax dipping. Talanta 85:2587–2593
Wang J, Monton MRN, Zhang X, Filipe CDM, Pelton R, Brennan JD (2014) Hydrophobic sol–gel channel patterning strategies for paper-based microfluidics. Lab Chip 14:691–695
Wu Y, Xue P, Kang Y, Hui KM (2013) Paper-based microfluidic electrochemical immunodevice integrated with nanobioprobes onto graphene film for ultrasensitive multiplexed detection of cancer biomarkers. Anal Chem 85:8661–8668
Acknowledgments
The authors thank John Zhu at the Melbourne Centre for Nanofabrication (MCN) in the Victorian Node of the Australian National Fabrication Facility (ANFF) for confocal imaging and technical help. Postgraduate research scholarships from Monash Graduate Education and Faculty of Engineering are gratefully acknowledged.
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Cao, R., Zhang, X., Tan, W. et al. Precipitation assay meets low wettability on paper: a simple approach for fabricating patterned paper sensors. Cellulose 25, 583–592 (2018). https://doi.org/10.1007/s10570-017-1551-z
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DOI: https://doi.org/10.1007/s10570-017-1551-z