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Construction and Characterization of Magnetic Fe3O4 Nanoparticles Supported Zn Complex: Research on Multicomponent Synthesis of Highly Functionalized Piperidines

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Abstract

In recent times, the research on the synthesis of highly functionalized piperidines has become a challenge and an attractive research field among synthetic chemists because these compounds have many biological, pharmaceutical and industrial applications. In this regard, in this paper we would like to report a green, rapid and efficient method for the synthesis of highly functionalized piperidines based on the use of zinc (II) chloride supported on Fe3O4 NPs modified with Dopamine and 5H-Cyclopenta[2,1-b:3,4-b′]dipyridin-5-one [Fe3O4@Dop/CP-diPy-ZnCl2 as a novel magnetically reusable catalyst. The structure of Fe3O4@Dop/CP-diPy-ZnCl2 nanocatalyst was well identified by several spectroscopic techniques including: FT-IR, TEM, SEM, EDX, ICP-OES, TGA, XRD, VSM and Elemental mapping technique. One-pot three-component reactions of aromatic amines with different aryl aldehydes and β-ketoesters were performed in water and all desired highly functionalized piperidines were synthesized with high to excellent yields, which indicates the high efficiency of this catalytic system. The reusability tests shown that that Fe3O4@Dop/CP-diPy-ZnCl2 catalyst is a reusable and stable catalyst.

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  1. Wuhan Polytechnic Bioengineering Institute, Wuhan, 430000, Hubei, China

    Zhao Yan Xia & Wu Wei

  2. Institute of Chemical Science and Technology, Guangzhou, China

    Li Yan Zhang

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Xia, Z.Y., Wei, W. & Zhang, L.Y. Construction and Characterization of Magnetic Fe3O4 Nanoparticles Supported Zn Complex: Research on Multicomponent Synthesis of Highly Functionalized Piperidines. Catal Lett (2024). https://doi.org/10.1007/s10562-024-04580-7

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