Abstract
Skeletal problems are an increasing issue due to the increase in the global aging population. Different statistics reports show that today, the global population is aging that results in skeletal problems, increased health system costs, and even higher mortality associated with skeletal problems. Common treatments such as surgery and bone grafts are not always effective and in some cases, they can even cause secondary problems such as infections or improper repair. Cell therapy is a method that can be utilized along with common treatments independently. Mesenchymal stem cells (MSCs) are a very important and efficient source in terms of different diseases, especially bone problems. These cells are present in different tissues such as bone marrow, adipose tissue, umbilical cord, placenta, dental pulp, peripheral blood, amniotic fluid and others. Among the types of MSCs, bone marrow mesenchymal stem cells (BMMSCs) are the most widely used source of these cells, which have appeared to be very effective and promising in terms of skeletal diseases, especially compared to the other sources of MSCs. This study focuses on the specific potential and content of BMMSCs from which the specific capacity of these cells originates, and compares their osteogenic potential with other types of MSCs, and also the future directions in the application of BMMSCs as a source for cell therapy.
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Acknowledgements
The authors are grateful to the staff and experts of the Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences for their help and support. This article was done with Grant No. (62516) and ethical number: (IR.TBZMED.REC.1398.039). This study was financially supported by the Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
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In connection with this review article, the main idea was given by LR. The initial draft of the article was written by MSGHF. AHM, MJ, JSR, SKSH and SHM critically revised the manuscript. The figure design of the article was done by MJ. Also, all authors commented on previous versions of the manuscript and they read and approved the final manuscript. In general, all authors were involved in writing and editing parts of this article. We declare that this manuscript is review, has not been published before and is not currently being considered for publication elsewhere. We understand that the Corresponding Author is the sole contact for the Editorial process. she is responsible for communicating with the other authors about progress, submissions, revisions and final approval of proofs.
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Gholami Farashah, M.S., Mohammadi, A., Javadi, M. et al. Bone marrow mesenchymal stem cells’ osteogenic potential: superiority or non-superiority to other sources of mesenchymal stem cells?. Cell Tissue Bank 24, 663–681 (2023). https://doi.org/10.1007/s10561-022-10066-w
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DOI: https://doi.org/10.1007/s10561-022-10066-w