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3.0 T unenhanced Dixon water-fat separation whole-heart coronary magnetic resonance angiography: compressed-sensing sensitivity encoding imaging versus conventional 2D sensitivity encoding imaging

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Abstract

This study was aimed to investigate 3.0 T unenhanced Dixon water-fat whole-heart CMRA (coronary magnetic resonance angiography) using compressed-sensing sensitivity encoding (CS-SENSE) and conventional sensitivity encoding (SENSE) in vitro and in vivo. The key parameters of CS-SENSE and conventional 1D/2D SENSE were compared in vitro phantom study. In vivo study, fifty patients with suspected coronary artery disease (CAD) completed unenhanced Dixon water-fat whole-heart CMRA at 3.0 T using both CS-SENSE and conventional 2D SENSE methods. We compared mean acquisition time, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and the diagnostic accuracy between two techniques. In vitro study, CS-SENSE achieved better effectiveness between higher SNR/CNR and shorter scan times using the appropriate acceleration factor compared with conventional 2D SENSE. In vivo study, CS-SENSE CMRA had better performance than 2D SENSE in terms of the mean acquisition time, SNR and CNR (7.4 ± 3.2 min vs. 8.3 ± 3.4 min, P = 0.001; SNR: 115.5 ± 35.4 vs. 103.3 ± 32.2; CNR: 101.1 ± 33.2 vs. 90.6 ± 30.1, P < 0.001 for both). The diagnostic accuracy between CS-SENSE and 2D SENSE had no significant difference on a patient-based analysis (sensitivity: 97.3% vs. 91.9%; specificity: 76.9% vs. 61.5%; accuracy: 92.0% vs. 84.0%; P > 0.05 for each). Unenhanced CS-SENSE Dixon water-fat separation whole-heart CMRA at 3.0 T can improve the SNR and CNR, shorten the acquisition time while providing equally satisfactory image quality and diagnostic accuracy compared with 2D SENSE CMRA.

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Acknowledgements

The authors are grateful to Jianying Ma and Zhangwei Chen for evaluation the images of coronary angiography in the study.

Funding

This work was supported by the Science Foundation of Shanghai Municipal Health Commission, (202040349) Dr. Hang Jin; Shanghai Pujiang Program (21PJD012) Dr. Yin-yin Chen; Scientific Research and Development Program of Shanghai Shenkang Hospital development center (SKLY2022CRT201) Dr. Mengsu Zeng; Shanghai Municipal Key Clinical Specialty (shslczdzk03202) Dr. Mengsu Zeng.

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Authors and Affiliations

  1. Department of Radiology, Zhongshan Hospital, Fudan University and Shanghai Institute of Medical Imaging, No. 180 Fenglin Rd, Shanghai, 200032, China

    Di Tian, Yi Sun, Jia-jun Guo, Shi-hai Zhao, Hong-fei Lu, Yin-yin Chen, Mei-ying Ge, Meng-su Zeng & Hang Jin

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  1. Di Tian
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Contributions

Hang Jin, Mei-ying Ge and Shi-hai Zhao contributed to the conception and study design. Yin-yin Chen, Hang Jin contributed to image reconstruction and analysis of CMRA images.Yi Sun contributed to statistical analysis. Di Tian drafted together with Yi Sun. Jia-jun Guo and Hong-fei Lu helped to revise the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Mei-ying Ge or Hang Jin.

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Competing interests

The authors have no relevant financial or non-financial interests to disclose.

Ethics approval and consent to participate

The patient studies were approved by our institutional Ethical Review Board and conducted in accordance with the Declaration of Helsinki. All patients gave written informed consent prior to enrollment.

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Di Tian, Yi Sun and Jia-jun Guo contributed equally to this work.

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Tian, D., Sun, Y., Guo, Jj. et al. 3.0 T unenhanced Dixon water-fat separation whole-heart coronary magnetic resonance angiography: compressed-sensing sensitivity encoding imaging versus conventional 2D sensitivity encoding imaging. Int J Cardiovasc Imaging 39, 1775–1784 (2023). https://doi.org/10.1007/s10554-023-02878-y

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