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Prostate cancer clinical presentation, incidence, mortality and survival in Guadeloupe over the period 2008–2013 from a population-based cancer registry

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Abstract

Purpose

The Caribbean population of Guadeloupe has one of the highest incidence rates of prostate cancer worldwide. In 2008, a population-based cancer registry was set up for the monitoring of cancer incidence in the aftermath of the environmental pollution with chlordecone, a persistent organochlorine insecticide formerly used in banana plantations. We describe the clinical presentation, incidence, mortality and survival of prostate cancer for the period 2008–2013.

Methods

The Guadeloupe cancer registry has been routinely collecting all incident cases of cancer since 2008. We compared age-specific incidence rates between different populations, and calculated incidence and mortality rates standardized to the world population. Kaplan–Meier observed survival and estimated age-standardized net survival were calculated by category for age, PSA level, and Gleason score using the Pohar-Perme method.

Results

Overall, 3,295 cases of prostate cancer were recorded. World-standardized incidence and mortality were respectively 184.1 [177.8–190.4] and 23.9 [21.9–25.7] per 100,000 person-years. At diagnosis, the mean age of patients was 68 ± 9.6 years old and 22% were aged over 75. Median PSA level was 8.9 [IQR: 6.0–16.0] and 13.6% of the patients had a Gleason ≥ 8. Five-year observed and net survivals were, respectively, 79.6% [77.9–81.2] and 90.7% [88.6–92.8].

Conclusion

The incidence of prostate cancer in Guadeloupe is among the highest in the world, along with those of the neighboring Caribbean countries and US African-Americans. We observed no decrease in incidence rates, and a decreasing but non-significant trend in mortality rates, which nonetheless remain higher than in high-income countries. Many Genome-Wide Association Studies are conducted to identify genetic markers involved in prostate cancer risk. In the Caribbean, complementary studies on both lifestyle and behavioral factors should highlight potential common risks among populations who share both genetic and environmental characteristics.

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Funding

The cancer registry of Guadeloupe receives financial support from l’Institut National du Cancer (INCa) and Santé Publique France.

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Authors and Affiliations

  1. Registre général des cancers de Guadeloupe, Centre Hospitalier Universitaire de Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France

    J. Deloumeaux & B. Bhakkan

  2. Service d’Urologie, Centre Hospitalier Universitaire de Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France

    R. Eyraud, P. Blanchet & L. Brureau

  3. Clinique des Eaux-Claires, Pointe-à-Pitre, Guadeloupe, France

    F. Braud

  4. Service d’Oncologie-Radiothérapie, Centre Hospitalier Universitaire de Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France

    N. Manip M’Ebobisse

  5. INSERM, U1085 - IRSET, 97145, Pointe-à-Pitre, Guadeloupe, France

    P. Blanchet & L. Brureau

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  1. J. Deloumeaux
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  2. B. Bhakkan
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  3. R. Eyraud
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  6. P. Blanchet
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  7. L. Brureau
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Correspondence to J. Deloumeaux.

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Deloumeaux, J., Bhakkan, B., Eyraud, R. et al. Prostate cancer clinical presentation, incidence, mortality and survival in Guadeloupe over the period 2008–2013 from a population-based cancer registry. Cancer Causes Control 28, 1265–1273 (2017). https://doi.org/10.1007/s10552-017-0962-3

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