Abstract
The purpose of this study was to examine post-diagnosis BMI, very low physical activity, and comorbidities, as predictors of breast cancer-specific and all-cause mortality. Data from three female US breast cancer survivor cohorts were harmonized in the After Breast Cancer Pooling Project (n = 9513). Delayed entry Cox proportional hazards models were used to examine the impact of three post-diagnosis lifestyle factors: body mass index (BMI), select comorbidities (diabetes only, hypertension only, or both), and very low physical activity (defined as physical activity <1.5 MET h/week) in individual models and together in multivariate models for breast cancer and all-cause mortality. For breast cancer mortality, the individual lifestyle models demonstrated a significant association with very low physical activity but not with the selected comorbidities or BMI. In the model that included all three lifestyle variables, very low physical activity was associated with a 22 % increased risk of breast cancer mortality (HR 1.22, 95 % CI 1.05, 1.42). For all-cause mortality, the three individual models demonstrated significant associations for all three lifestyle predictors. In the combined model, the strength and significance of the association of comorbidities (both hypertension and diabetes versus neither: HR 2.16, 95 % CI 1.79, 2.60) and very low physical activity (HR 1.35, 95 % CI 1.22, 1.51) remained unchanged, but the association with obesity was completely attenuated. These data indicate that after active treatment, very low physical activity, consistent with a sedentary lifestyle (and comorbidities for all-cause mortality), may account for the increased risk of mortality, with higher BMI, that is seen in other studies.
Similar content being viewed by others
References
DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS, Jemal A (2014) Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin 64(4):252–271. doi:10.3322/caac.21235
Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP (2001) The continuing epidemics of obesity and diabetes in the United States. JAMA 286(10):1195–1200
Ligibel JA, Alfano CM, Courneya KS, Demark-Wahnefried W, Burger RA, Chlebowski RT, Fabian CJ, Gucalp A, Hershman DL, Hudson MM, Jones LW, Kakarala M, Ness KK, Merrill JK, Wollins DS, Hudis CA (2014) American Society of Clinical Oncology position statement on obesity and cancer. J Clin Oncol 32(31):3568–3574. doi:10.1200/JCO.2014.58.4680
Flegal KM, Graubard BI, Williamson DF, Gail MH (2010) Sources of differences in estimates of obesity-associated deaths from first National Health and Nutrition Examination Survey (NHANES I) hazard ratios. Am J Clin Nutr 91(3):519–527. doi:10.3945/ajcn.2009.28222
Patterson RE, Flatt SW, Saquib N, Rock CL, Caan BJ, Parker BA, Laughlin GA, Erickson K, Thomson CA, Bardwell WA, Hajek RA, Pierce JP (2010) Medical comorbidities predict mortality in women with a history of early stage breast cancer. Breast Cancer Res Treat 122(3):859–865. doi:10.1007/s10549-010-0732-3
Hu FB, Li TY, Colditz GA, Willett WC, Manson JE (2003) Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA 289(14):1785–1791. doi:10.1001/jama.289.14.1785
Zhou Y, Zhao H, Peng C (2015) Association of sedentary behavior with the risk of breast cancer in women: update meta-analysis of observational studies. Ann Epidemiol. doi:10.1016/j.annepidem.2015.05.007
Nechuta SJ, Caan BJ, Chen WY, Flatt SW, Lu W, Patterson RE, Poole EM, Kwan ML, Chen Z, Weltzien E, Pierce JP, Shu XO (2011) The After Breast Cancer Pooling Project: rationale, methodology, and breast cancer survivor characteristics. Cancer Causes Control 22(9):1319–1331. doi:10.1007/s10552-011-9805-9
Pierce JP, Faerber S, Wright FA, Rock CL, Newman V, Flatt SW, Kealey S, Jones VE, Caan BJ, Gold EB, Haan M, Hollenbach KA, Jones L, Marshall JR, Ritenbaugh C, Stefanick ML, Thomson C, Wasserman L, Natarajan L, Thomas RG, Gilpin EA (2002) A randomized trial of the effect of a plant-based dietary pattern on additional breast cancer events and survival: the women’s healthy eating and living (WHEL) study. Controll Clin Trials 23(6):728–756
Caan B, Sternfeld B, Gunderson E, Coates A, Quesenberry C, Slattery ML (2005) Life after cancer epidemiology (LACE) study: a cohort of early stage breast cancer survivors (United States). Cancer Causes Control 16(5):545–556. doi:10.1007/s10552-004-8340-3
Colditz GA, Hankinson SE (2005) The nurses’ health study: lifestyle and health among women. Nat Rev Cancer 5(5):388–396. doi:10.1038/nrc1608
Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee (1995). World Health Organization technical report series 854:1–452
Sedentary Behaviour Research N (2012) Letter to the editor: standardized use of the terms “sedentary” and “sedentary behaviours”. Appl Physiol Nutr Metab 37(3):540–542. doi:10.1139/h2012-024
Johnson-Kozlow M, Rock CL, Gilpin EA, Hollenbach KA, Pierce JP (2007) Validation of the WHI brief physical activity questionnaire among women diagnosed with breast cancer. Am J Health Behav 31(2):193–202. doi:10.5555/ajhb.2007.31.2.193
Wolf AM, Hunter DJ, Colditz GA, Manson JE, Stampfer MJ, Corsano KA, Rosner B, Kriska A, Willett WC (1994) Reproducibility and validity of a self-administered physical activity questionnaire. Int J Epidemiol 23(5):991–999
Staten LK, Taren DL, Howell WH, Tobar M, Poehlman ET, Hill A, Reid PM, Ritenbaugh C (2001) Validation of the Arizona activity frequency questionnaire using doubly labeled water. Med Sci Sports Exerc 33(11):1959–1967
Ainsworth BE, Haskell WL, Leon AS, Jacobs DR Jr, Montoye HJ, Sallis JF, Paffenbarger RS Jr (1993) Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc 25(1):71–80
Pierce JP, Patterson RE, Senger CM, Flatt SW, Caan BJ, Natarajan L, Nechuta SJ, Poole EM, Shu XO, Chen WY (2014) Lifetime cigarette smoking and breast cancer prognosis in the After Breast Cancer Pooling Project. J Natl Cancer Inst 106(1):djt359. doi:10.1093/jnci/djt359
Chan DS, Vieira AR, Aune D, Bandera EV, Greenwood DC, McTiernan A, Navarro Rosenblatt D, Thune I, Vieira R, Norat T (2014) Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies. Ann Oncol 25(10):1901–1914. doi:10.1093/annonc/mdu042
Kroenke CH, Chen WY, Rosner B, Holmes MD (2005) Weight, weight gain, and survival after breast cancer diagnosis. J Clin Oncol 23(7):1370–1378. doi:10.1200/JCO.2005.01.079
Thivat E, Therondel S, Lapirot O, Abrial C, Gimbergues P, Gadea E, Planchat E, Kwiatkowski F, Mouret-Reynier MA, Chollet P, Durando X (2010) Weight change during chemotherapy changes the prognosis in non metastatic breast cancer for the worse. BMC Cancer 10:648. doi:10.1186/1471-2407-10-648
Nichols HB, Trentham-Dietz A, Egan KM, Titus-Ernstoff L, Holmes MD, Bersch AJ, Holick CN, Hampton JM, Stampfer MJ, Willett WC, Newcomb PA (2009) Body mass index before and after breast cancer diagnosis: associations with all-cause, breast cancer, and cardiovascular disease mortality. Cancer Epidemiol Biomark Prev 18(5):1403–1409. doi:10.1158/1055-9965.EPI-08-1094
Caan BJ, Kwan ML, Hartzell G, Castillo A, Slattery ML, Sternfeld B, Weltzien E (2008) Pre-diagnosis body mass index, post-diagnosis weight change, and prognosis among women with early stage breast cancer. Cancer Causes Control 19(10):1319–1328. doi:10.1007/s10552-008-9203-0
Caan BJ, Emond JA, Natarajan L, Castillo A, Gunderson EP, Habel L, Jones L, Newman VA, Rock CL, Slattery ML, Stefanick ML, Sternfeld B, Thomson CA, Pierce JP (2006) Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer. Breast Cancer Res Treat 99(1):47–57. doi:10.1007/s10549-006-9179-y
Ewertz M (1993) Breast cancer in Denmark. Incidence, risk factors, and characteristics of survival. Acta Oncol 32(6):595–615
Blair SN, Brodney S (1999) Effects of physical inactivity and obesity on morbidity and mortality: current evidence and research issues. Med Sci Sports Exerc 31(11 Suppl):S646–S662
Kushi LH, Fee RM, Folsom AR, Mink PJ, Anderson KE, Sellers TA (1997) Physical activity and mortality in postmenopausal women. JAMA 277(16):1287–1292
Schmid D, Leitzmann MF (2014) Association between physical activity and mortality among breast cancer and colorectal cancer survivors: a systematic review and meta-analysis. Ann Oncol 25(7):1293–1311. doi:10.1093/annonc/mdu012
Adams SA, Matthews CE, Ebbeling CB, Moore CG, Cunningham JE, Fulton J, Hebert JR (2005) The effect of social desirability and social approval on self-reports of physical activity. Am J Epidemiol 161(4):389–398. doi:10.1093/aje/kwi054
Prince SA, Adamo KB, Hamel ME, Hardt J, Connor Gorber S, Tremblay M (2008) A comparison of direct versus self-report measures for assessing physical activity in adults: a systematic review. The Int J Behav Nutr Phys Act 5:56. doi:10.1186/1479-5868-5-56
Acknowledgments
This Pooling Project was supported by the National Cancer Institute at the National Institutes of Health (3R01 CA118229-03S1). Additional support was provided by the National Cancer Institute (1R03CA171013 and F31CA183125). Support for the individual cohorts included in the present report came from women’s healthy eating & living study (Susan G. Komen Foundation, KG100988); Life After Cancer Epidemiology Study (National Cancer Institute, R01 CA129059); and the Nurses’ Health Study (P01 CA87969 and UM1 CA186107).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Nelson, S.H., Marinac, C.R., Patterson, R.E. et al. Impact of very low physical activity, BMI, and comorbidities on mortality among breast cancer survivors. Breast Cancer Res Treat 155, 551–557 (2016). https://doi.org/10.1007/s10549-016-3694-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10549-016-3694-2