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Association study of susceptibility loci with specific breast cancer subtypes in Chinese women

  • Preclinical study
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Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

To determine whether recent genome-wide association studies that reported 45 susceptibility loci in European women are also risk factors for breast cancer in Chinese women. We selected and genotyped 40 single nucleotide polymorphisms (SNPs) using the Sequenom iPlex platform in a female Chinese cohort of 2,901 breast cancer cases and 2,789 healthy controls. We evaluated these SNPs with the risk of breast cancer and further by estrogen receptor (ER) status, progestin (PR) status, human epidermal growth factor receptor-2 (HER-2) status, and four breast cancer subtypes (Luminal A type, Luminal B type, HER-2 overexpression type and Basal-like type). We first confirmed that the SNP rs9693444 on 8p12 was associated with breast cancer in Chinese women (P = 6.44 × 10−4). Furthermore, we identified four susceptibility loci that were associated with specific tumor subtypes. Statistically significant differences were detected with the association of rs6828523 (4q34.1/ADAM29) with ER-positive breast cancer (P = 1.27 × 10−3) and the association of rs4849887 (2q14.2) with PR-positive breast cancer (P = 1.29 × 10−3). Of the four breast cancer subtypes, the associations of rs12493607 (3p24.1/TGFBR2) with HER-2 overexpression in breast cancer (P = 1.09 × 10−3) and rs11075995 (16q12.2/FTO) with basal-like breast cancer (P = 1.64 × 10−4) were statistically significant. This study is the first to show that these 5 susceptibility loci (8p12, 4q34.1/ADAM29, 2q14.2, 3p24.1/TGFBR2, and 16q12.2/FTO) correlate with breast cancer (overall and specific subtypes) in Chinese women, which has improved our understanding of the genetic basis of specific breast cancer subtypes.

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Acknowledgments

We thank all participants and the volunteers who have so willingly participated in this study, which thus made this study possible.

Conflict of interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Department of Oncology at No. 2 Hospital, Anhui Medical University, Furong Rd. 688, Economic Development District, Hefei, Anhui, China

    Bo Zhang, Zhong-lian Huang, Han Xuan, Wei Li & Zhen-dong Chen

  2. School of Life Sciences, Anhui Medical University, Hefei, Anhui, China

    Bo Zhang & Mengyun Chen

  3. Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui, China

    Yang Li, Longnian Li, Cuicui Zhang, Xian-bo Zuo, Fu-sheng Zhou, Bo Liang, Jun Zhu & Pan Li

  4. Department of Dermatology and Venereology, Anhui Medical University, Hefei, Anhui, China

    Yang Li, Longnian Li, Xian-bo Zuo, Fu-sheng Zhou, Bo Liang, Jun Zhu & Pan Li

  5. State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Hefei, Anhui, China

    Yang Li, Longnian Li, Xian-bo Zuo, Fu-sheng Zhou, Bo Liang, Jun Zhu & Pan Li

Authors
  1. Bo Zhang
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  2. Yang Li
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  3. Longnian Li
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  7. Fu-sheng Zhou
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  8. Bo Liang
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  11. Zhong-lian Huang
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  12. Han Xuan
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  13. Wei Li
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  14. Zhen-dong Chen
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Correspondence to Bo Zhang.

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Cite this article

Zhang, B., Li, Y., Li, L. et al. Association study of susceptibility loci with specific breast cancer subtypes in Chinese women. Breast Cancer Res Treat 146, 503–514 (2014). https://doi.org/10.1007/s10549-014-3041-4

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  • DOI: https://doi.org/10.1007/s10549-014-3041-4

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