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Influence of boost radiotherapy in patients with ductal carcinoma in situ breast cancer: a multicenter, retrospective study in Korea (KROG 11-04)

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Abstract

To estimate the effect of boost radiotherapy on local recurrence-free survival (LRFS) in patients with ductal carcinoma in situ (DCIS) breast cancer. We included patients from nine institutions who met the following criteria: having Tis, age 18 years or older, having breast conserving surgery (BCS) and radiotherapy within 12 weeks after surgery. From 1995 through 2006, 728 patients were analyzed retrospectively by the Korean Radiation Oncology Group. All patients received whole-breast radiation therapy (WBRT) after BCS. 232 patients (31.9 %) also received boost radiation therapy (RT) (median 10 Gy). After median follow-up of 82 months, 5-year LRFS was 98.4 % and 10-year LRFS was 95.8 % for all patients. There was no statistically significant difference of LRFS between the boost and no-boost groups. Nineteen (2.6 %) patients had ipsilateral breast recurrences, including 12 of invasive recurrence and 7 DCIS. The presence of the HER2 receptor was associated with more invasive recurrences. Nine (1.2 %) patients developed contralateral breast cancer, including six invasive breast cancer and three DCIS. In the multivariate analysis, only the margin status was a significant prognostic factor for LRFS. Boost RT was not associated with further improvement of local control in DCIS after BCS and WBRT. HER2 receptor-positive patients may need further treatment with the anti-HER2 agents.

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Authors and Affiliations

  1. Department of Radiation Oncology, Dongsan Medical Center, Keimyung University School of Medicine, 56 Dalseong-Ro, Jung-Gu, Daegu, Korea

    Jin Hee Kim

  2. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro Gangnam-gu, Seoul, Korea

    Doo Ho Choi & Won Park

  3. Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    Seung Do Ahn & Su Ssan Kim

  4. Seoul National University Hospital, Seoul, Korea

    Sung Whan Ha & Kyubo Kim

  5. Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

    Yong Bae Kim & Chang-Ok Suh

  6. Yeungnam University College of Medicine, Daegu, Korea

    Ji Woon Yea & Min Kyu Kang

  7. National Cancer Center, Ilsan, Korea

    Kyung Hwan Shin

  8. Pusan National University Hospital, Pusan, Korea

    Dong Won Kim

  9. Ewha Womans University Mokdong Hospital, Seoul, Korea

    Ji Hae Lee

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  1. Jin Hee Kim
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  2. Doo Ho Choi
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Correspondence to Jin Hee Kim or Doo Ho Choi.

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Kim, J.H., Choi, D.H., Park, W. et al. Influence of boost radiotherapy in patients with ductal carcinoma in situ breast cancer: a multicenter, retrospective study in Korea (KROG 11-04). Breast Cancer Res Treat 146, 341–345 (2014). https://doi.org/10.1007/s10549-014-3025-4

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  • DOI: https://doi.org/10.1007/s10549-014-3025-4

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