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EEG Spatial-temporal Dynamics of Resting-state Activity in Young Women with Anorexia Nervosa: Preliminary Evidence

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Abstract

The aim of this study was to provide preliminary evidence on temporal dynamics of resting-state brain networks in youth with anorexia nervosa (AN) using electroencephalography (EEG). Resting-state EEG data were collected in 18 young women with AN and 18 healthy controls (HC). Between-group differences in brain networks were assessed using microstates analyses. Five microstates were identified across all subjects (A, B, C, D, E). Using a single set of maps representative of the whole dataset, group differences were identified for microstates A, C, and E. A common-for-all template revealed a relatively high degree of consistency in results for reduced time coverage of microstate C, but also an increased presence of microstate class E. AN and HC had different microstate transition probabilities, largely involving microstate A. Using LORETA, for microstate D, we found that those with AN had augmented activations in the left frontal inferior operculum, left insula, and bilateral paracentral lobule, compared with HC. For microstate E, AN had augmented activations in the para-hippocampal gyrus, caudate, pallidum, cerebellum, and cerebellar vermis. Our findings suggest altered microstates in young women with AN associated with integration of sensory and bodily signals, monitoring of internal/external mental states, and self-referential processes. Future research should examine how EEG-derived microstates could be applied to develop diagnostic and prognostic models of AN.

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Acknowledgements

This work was supported by the Foundation Gertrude von Meissner and the ‘Fondation Ernst et Lucie Schmidheiny’ (to CB and NM).

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Authors and Affiliations

  1. Group of Psychiatric Neuroscience, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Piazza Giulio Cesare, 11, 70121, Bari, Italy

    Cristina Berchio

  2. Department of Psychology, University of Cambridge, Cambridge, UK

    Samika S. Kumar

  3. Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD, USA

    Samika S. Kumar

  4. Great Ormond Street Institute of Child Health, University College London, London, UK

    Nadia Micali

  5. Mental Health Services in the Capital Region of Denmark, Eating Disorders Research Unit, Psychiatric Centre Ballerup, Ballerup, Denmark

    Nadia Micali

  6. Institute of biological Psychiatry, Psykiatrisk Center Sct. Hans, Region Hovedstaden, Denmark

    Nadia Micali

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Contributions

Conception and design: C.B, N.M.; Data acquisition: C.B.; Data analysis: C.B., N.M.; Writing of the manuscript: C.B., S.K., N.M.; Editing: S.K. All authors read and approved the final manuscript.

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Correspondence to Cristina Berchio.

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Berchio, C., Kumar, S.S. & Micali, N. EEG Spatial-temporal Dynamics of Resting-state Activity in Young Women with Anorexia Nervosa: Preliminary Evidence. Brain Topogr 37, 447–460 (2024). https://doi.org/10.1007/s10548-023-01001-7

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