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Looking for a partner: ceruloplasmin in protein–protein interactions

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Abstract

Ceruloplasmin (CP) is a mammalian blood plasma ferroxidase. More than 95% of the copper found in plasma is carried by this protein, which is a member of the multicopper oxidase family. Proteins from this group are able to oxidize substrates through the transfer of four electrons to oxygen. The essential role of CP in iron metabolism in humans is particularly evident in the case of loss-of-function mutations in the CP gene resulting in a neurodegenerative syndrome known as aceruloplasminaemia. However, the functions of CP are not limited to the oxidation of ferrous iron to ferric iron, which allows loading of the ferric iron into transferrin and prevents the deleterious reactions of Fenton chemistry. In recent years, a number of novel CP functions have been reported, and many of these functions depend on the ability of CP to form stable complexes with a number of proteins.

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Acknowledgements

The author is grateful to Dr. Alexey Sokolov (Institute of Experimental Medicine, Saint-Petersburg) and Dr. Valeria Samygina (Institute of Crystallography, Moscow) for help and fruitful consultations.

Funding

This work was supported by Grant 18-015-00241 from the Russian Foundation for Basic Research.

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  1. Institute of Experimental Medicine, 12 Acad. Pavlov Street, Saint Petersburg, Russia, 197376

    Vadim B. Vasilyev

  2. Saint Petersburg State University, 4-7 University Embankment, Saint Petersburg, Russia, 199034

    Vadim B. Vasilyev

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Vasilyev, V.B. Looking for a partner: ceruloplasmin in protein–protein interactions. Biometals 32, 195–210 (2019). https://doi.org/10.1007/s10534-019-00189-1

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