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Perspectives of nervonic acid production by Yarrowia lipolytica

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A Correction to this article was published on 19 May 2022

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Abstract

Nervonic acid (cis-15-tetracosenoic acid, 24:1Δ15) is a long chain monounsaturated fatty acid, mainly exists in white matt er of the human brains. It plays an important role in the development of nervous system and curing neurological diseases. The limited natural sources and high price are considered limiting factors for the extensive application of nervonic acid. Yarrowia lipolytica is a high lipid producing yeast and engineered strain which can produce nervonic acid. The biosynthesis of nervonic acid has yet to be investigated, although the metabolism has been examined for couple of years. Normally, oleic acid is considered the origin of nervonic acid synthesis through fatty acid prolongation, where malonyl-CoA and acyl-CoA are initially concise by 3-ketoacyl-CoA synthase (KCS). To meet the high requirement of industrial production, the optimization of fermentation and bioreactors configurations are necessary tools to be carried out. This review article summarizes the research literature on advancements and recent trends about the production, synthesis and properties of nervonic acid.

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Acknowledgements

This work was supported by the Major Science and Technology Program for Water Pollution Control and Treatment of China (Grant No. 2017ZX07102-004), National Key Technology Support Program of China (Grant No. 2014BAC27B01), National Natural Science Foundation of China (No. 31770077), the “Transformational Technologies for Clean Energy and Demonstration”, Strategic Priority Research Program of the Chinese Academy of Sciences (XDA 21060400), and QIBEBT (Grant: QIBEBT-ZZBS 201805). We are grateful to CAS President’s International Fellowship Initiative Program for additional financial support. We are also thankful to the University of Chinese Academy of Sciences and Directorate of Colleges, Higher Education, Archives and Libraries Department, Government of Khyber Pakhtunkhwa, Pakistan for administrative support.

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  1. School of Human Settlements and Environment, Nanchang Institute of Science and Technology, Nanchang, 330108, China

    Abdulmoseen Segun Giwa

  2. State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing, 100084, China

    Abdulmoseen Segun Giwa & Nasir Ali

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The original online version of this article was revised: The word Arabian Gulf is replaced with Persian Gulf in the text.

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Giwa, A.S., Ali, N. Perspectives of nervonic acid production by Yarrowia lipolytica. Biotechnol Lett 44, 193–202 (2022). https://doi.org/10.1007/s10529-022-03231-4

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