Skip to main content
SpringerLink
Log in

A Portable Optical Device for Assessing Platelet Aggregation Activity

  • Published:
Biomedical Engineering Aims and scope

A portable device for point-of-care testing of native human blood has been developed. The device operation is based on digital speckle pattern correlation. This study is a continuation of a series of reports on the use of the digital speckle pattern correlation method for analysis of the functional state of the hemostasis system. We show that native blood can be analyzed using the laser speckle pattern correlation method for qualitative assessment of the state of the hemostasis system and for determination of platelet aggregation time. Results obtained using the device prototype are compared with results obtained using the Mednord low-frequency piezothromboelastograph (NPTEG).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Karpishchenko, A. I., Andreev, V. A., Antonov, V. G., et al., Medical Laboratory Diagnostics: Programs and Algorithms. Guidelines for Doctors [in Russian], Karpishchenko, A. I. (ed.), GEOTAR-Media, Moscow (2014).

  2. Levi, M. and Hunt, B. J., “A critical appraisal of point-of-care coagulation testing in critically ill patients,” J. Thromb. Haemost., No. 13 (11), 1960-1967 (2015).

  3. Luo, D., Chelales, E. M., Beard, M. M., Kasireddy, N., and Khismatullin, D. B., “Drop-of-blood acoustic tweezing technique for integrative turbidimetric and elastometric measurement of blood coagulation,” Anal. Bioanal., Chem., No. 413, 3369-3379 (2021).

  4. Sharma, S., Kumar, S., Tewari, P., Pande, S., and Murari, M., “Utility of thromboelastography versus routine coagulation tests for assessment of hypocoagulable state in patients undergoing cardiac bypass surgery,” Ann. Card. Anaesth., 21, No. 2, 151-157 (2018).

    PubMed  PubMed Central  Google Scholar 

  5. Mij in, J., Arum, H., Hyeran, K., Kyoo-Hyung, L., Je-Hwan, L., and Jung-Hee, L., “A comparison of coagulation test results from heparinized central venous catheter and venipuncture,” Blood Coagul. Fibrinolysis, 31, No. 2, 145-151 (2020).

  6. Pekelharing, J., Furck, A., Banya, W., Macrae, D., and Davidson, S. J., “Comparison between thromboelastography and conventional coagulation tests after cardiopulmonary bypass surgery in the paediatric intensive care unit,” Int. J. Lab. Hematol., 36, No. 4, 465-471 (2014).

    Article  CAS  Google Scholar 

  7. Solov’ev, M. A., Tyutrin, I. I., Udut, V. V., and Klimenkova, V. F., “Experience of the diagnosis and monitoring of critical impairments to hemostasis,” Med. Biol. Sots. Psikhol. Prob. Bezopasn. Chrezvych. Situats., No. 4, 55-60 (2013).

  8. Bolliger, D. and Tanaka, K. A., “Point-of-care coagulation testing in cardiac surgery,” Semin. Thromb. Hemost., 43, No. 4, 386-396 (2017).

    Article  Google Scholar 

  9. Kumar, S., Nehra, M., Khurana, S., Dilbaghi, N., Kumar, V., Kaushik, A., and Kim, K. H., “Aspects of point-of-care diagnostics for personalized health wellness,” Int. J. Nanomedicine, 16, 383-402 (2021).

    Article  Google Scholar 

  10. Sahli, S. D., Rössler, J., Tscholl, D. W., Studt, J. D., Spahn, D. R., and Kaserer, A., “Point-of-care diagnostics in coagulation management,” Sensors (Basel), 20, No. 15, 4254 (2020).

  11. Angiolillo, D. J., Been, L., Rubinstein, M., Martin, M., Rollini, F., and Franchi, F., “Use of the VerifyNow point of care assay to assess the pharmacodynamic effects of loading and maintenance dose regimens of prasugrel and ticagrelor,” J. Thromb. Thrombolysis, 51, 741-747 (2021).

    Article  CAS  Google Scholar 

  12. Schultz-Lebahn, A., Skipper, M. T., Hvas, A. M., and Larsen, O. H., “Optimized tool for evaluation of platelet function measured by impedance aggregometry,” Platelets, 32, No. 6, 842-845 (2021).

  13. Slizevich, D. S., Gubarev, F. A., and Tyutrin, I. I., “A hardware and software system for point-of-care testing of the functional state of the hemostasis system,” Biomed. Eng., 55, 164-168 (2021).

    Article  Google Scholar 

  14. Mednord-Tekhnika, Production and Sale of Medical Equipment [in Russian], [online resource]; http:mednord-t.ru/ (accessed December 29, 2021).

  15. Hanson, S. R., Tucker, E. I., and Latour, R. A., “Blood coagulation and blood-material interactions,” in: Biomaterials Science: An Introduction to Materials in Medicine, Wagner, W. R., Sakiyama-Elbert, S. E., Zhang, G., and Yaszemski, M. J., (eds.), Academic Press, Cambridge, MA (2020), pp. 801-812.

  16. Li, L., Sytnik, Yu. D., Gubarev, F. A., and Pekker, Y. S., “Evaluation of blood plasma coagulability by laser speckle correlation,” Biomed. Eng., 52, 177-180 (2018).

    Article  Google Scholar 

  17. Liushnevskaya, Yu. D., Gubarev, F. A., Li, L., Nosarev, A. V., and Gusakova, V. S., “Measurement of whole blood coagulation time by laser speckle pattern correlation,” Biomed. Eng., 54, 262-266 (2020).

    Article  Google Scholar 

  18. Sytnik, I. D., Gubarev, F. A., and Li, L., “A prototype of optical blood coagulometer,” in: 2019 20th International Conference of Young Specialists on Micro/Nanotechnologies and Electron Devices (EDM), IEEE, Erlagol (Altai Republic), 593-596 (2019).

  19. Zheng, Q., Mashiwa, N., and Furushima, T., “Evaluation of large plastic deformation for metals by a non-contacting technique using digital image correlation with laser speckles,” Materials & Design, 191, Art. No. 108626 (2020).

  20. Pan, B., “Digital image correlation for surface deformation measurement: Historical developments, recent advances and future goals,” Meas. Sci. Technol., 29, No. 8, (2018).

  21. Etchepareborda, P., Moulet, M.-H., and Melon, M., “Random laser speckle pattern projection for non-contact vibration measurements using a single high-speed camera,” Mech. Syst. Signal Proc., 158, Art. No. 107719 (2021).

  22. Li, L., Gubarev, F. A., Cao, Y., Liushnevskaya, I. D., and Mostovshchikov, A. V., “Laser speckle correlation technique application for remote characterization of metal nanopowder combustion,” Applied Optics, 60, No. 22, 6585-6592 (2021).

  23. Yokoi, T., Aizu, Y., and Uozumi, J., “Analysis of blood coagulation process based on fractality and dynamic characteristic of laser speckle pattern,” J. Biomed. Opt., 24, No. 3, Art. No. 031018 (2018).

  24. Khaksari, K. and Kirkpatrick, S. J., “Laser speckle contrast imaging is sensitive to advective flux,” J. Biomed. Opt., 21, No. 7, 076001, 1-8 (2016).

  25. Hild, F., Bouterf, A., Forquin, P., and Roux, F. S., “On the use of digital image correlation for the analysis of the dynamic behavior of materials,” in: The Micro-World Observed by Ultra High-Speed Cameras, Springer, Champaign (2017), pp. 185-206.

Download references

Author information

Authors and Affiliations

  1. National Research Tomsk Polytechnic University, Tomsk, Russia

    Yu. D. Liushnevskaya, F. A. Gubarev & D. S. Slizevich

  2. OOO Mednord-Tekhnika, Tomsk, Russia

    D. S. Slizevich

Authors
  1. Yu. D. Liushnevskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. A. Gubarev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. S. Slizevich
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yu. D. Liushnevskaya.

Additional information

Translated from Meditsinskaya Tekhnika, Vol. 56, No. 3, May-Jun., 2022, pp. 8-11.

Rights and permissions

Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liushnevskaya, Y.D., Gubarev, F.A. & Slizevich, D.S. A Portable Optical Device for Assessing Platelet Aggregation Activity. Biomed Eng 56, 160–164 (2022). https://doi.org/10.1007/s10527-022-10205-3

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10527-022-10205-3

Search

Navigation