The task of developing means of forming biocoatings improving the characteristics of metal implant bases remains important and current in contemporary implantology. Creation of bioactive layers with high levels of compatibility with bone tissue on implant surfaces is beneficial for better adaptation of the body to the implant. Introduction of such coatings, lacking adverse (toxic) actions, into the living body should strengthen osteointegration with bone tissue and stimulate regeneration processes. Bioactive calcium phosphate layers are of particular interest, as these contain calcium phosphate, which is “native” to bone tissue. Studies in this direction will lead to the development of a new method in medicine − bone tissue engineering. A means of forming a calcium phosphate coating on the medical titanium alloy BT6 (Ti containing 3.5-5.3% by weight V, 5.3-6.8% Al) by plasma electrolytic oxidation (PEO) was developed. The calcium phosphate coating was obtained in a bipolar PEO regime in a glycerophosphate-containing electrolyte. The osteogenerating properties of the coating were assessed in fractures of the diaphyseal part of the femur in Wistar lab rats. The calcium phosphate PEO coating was found to accelerate osteogenesis and promoted the formation of good periosteal callus at the fracture site.
Similar content being viewed by others
References
Bordji, K., Jouzeay, J. Y., Mainard, D., Payan, E., Netter, P., Rie, K. T., Stucky, T., and Hage, M. A., “Cytocompatibility of Ti–6Al–4V and Ti–5Al–2.5Fe alloys according to three surface treatments, using human fibroblasts and osteoblasts,” Biomaterials, 17, 929-940 (1996).
Bruni, S., Martinesi, M., Stio, M., Treves, C., Bacci, T., and Borgioli, F., “Effects of surface treatment of Ti–6Al–4V titanium alloy on biocompatibility in cultured human umbilical vein endothelial cells,” Acta Biomater., 1, 223-234 (2005).
Kohn, D. H., “Metals in medical applications,” Curr. Opin. Solid State Mat. Sci., 3, 309-316 (1998).
Jacobs, J. J., Skipor, A. K., Black, J., Urban, R. M., and Galante, J. O., “Release and excretion of metal in patients who have a total hip replacement component made of titanium-base alloy,” J. Bone Joint Surg., 73, No. 10, 1475-1486 (1991).
Okazaki, Y. and Gotoh, E., “Comparison of metal release from various metallic biomaterials in vitro,” Biomaterials, 26, 11-21 (2005).
Haynes, D. R., Rogers, S. D., Hay, S., Pearcy, M. J., and Howie, D. W., “The differences in toxicity and release of bone-resorbing mediators induced by titanium and cobalt–chromium-alloy wear particles,” J. Bone Joint Surg., 75, No. 6, 825-834 (1993).
Groot, K., Geesink, R., Klein, C., and Serekian, P., “Plasma sprayed coatings of hydroxyapatite,” J. Biomed. Mater. Res., 21, 1375-1381 (2004).
Kashuro, V. A., Fomina, M. A., Rodionov, I. V., and Fomin, A. A., “Nanoporous structure of coatings formed by gas-thermal spraying of electrocorundum followed by micro-arc oxidation on titanium alloy BT6 implants,” Med. Tekhnika, No. 1, 38-41 (2016).
Cleries, L., Martinez, E., Fernandez-Pradas, J., Sardin, G., Esteve, J., and Morenza, J., “Mechanical properties of calcium phosphate coatings deposited by laser ablation,” Biomaterials, 21, 967-971 (2000).
Han, Y., Fu, T., Lu, J., and Xu, K., “Characterization and stability of hydroxyapatite coatings prepared by an electrodeposition and alkaline_treatment process,” J. Biomed. Mater. Res., 54, 96-101 (2000).
Habibovic, P., Barrere, F., Blitterswijk, C. A., Groot, K., and Layrolle, P., “Biomimetic hydroxyapatite coating on metal implants,” J. Am. Cer. Soc., 85, 517-522 (2002).
Kolobov, Yu. R., Sharkeev, Yu. P., Karlov, A. V., Legostaeva, E. V., Shashkina, G. A., Khlusov, I. A., Bratchikov, A. D., Eroshenko, A. Yu., Pozhen’ko, N. S., and Shashkin, A. B., “Biocomposite materials with high compatibility for traumatology and orthopaedics,” Deformats. Razrush. Mater., No. 4, 2-9 (2005).
Shashkina, G. A., Sharkeev, Yu. P., Kolobov, Yu. R., and Karlov, A. V., “A calcium phosphate coating on titanium and titanium alloys and a means for its application,” Russian Federation Patent No. 2291918 (2005); Byul. Izobret., No. 56 (2007).
Sharkeev, Yu. P., Psakh’e, S. G., et al., Biocomposites based on Calcium Phosphate Coatings of Nanostructured and Ultrafinely Grained Bioinert Metals, their Biocompatibility, and Biodegradation [in Russian], Tomsk State University Press, Tomsk (2014).
Gnedenkov, S. V., Sharkeev, Yu. P., Sinebryukhov, S. L., Khrisanfova, O. A., Legostaeva, E. V., Zavidnaya, A. G., Puz’, A. V., Khlusov, I. A., and Opra, D. P., “Functional coatings formed on the titanium and magnesium alloys as implant materials by plasma electrolytic technique: Fundamental principles and synthesis conditions,” Corros. Rev., 34, No. 1-2, 65-83 (2016).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Meditsinskaya Tekhnika, Vol. 51, No. 2, Mar.-Apr., 2017, pp. 30-32.
Rights and permissions
About this article
Cite this article
Gnedenkov, S.V., Sinebryukhov, S.L., Puz’, A.V. et al. In vivo Osteogenerating Properties of Calcium Phosphate Coatings on Ti-6Al-4V Titanium Alloy. Biomed Eng 51, 116–119 (2017). https://doi.org/10.1007/s10527-017-9696-5
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10527-017-9696-5