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Morphopathological Effect of Ferrihydrite Nanoparticles in an Experimental Model of Toxic Hemolytic Anemia

  • PHARMACOLOGY AND TOXICOLOGY
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We studied the effect of biogenic ferrihydrite nanoparticles synthesized as a result of the culturing of Klebsiella oxytoca on Wistar rats with experimental toxic hemolytic anemia. The pathology was simulated by single intraperitoneal injection of phenylhydrazine hydrochloride. On day 4, the functional parameters of erythrocytes in rats corresponded to the state of toxic hemolytic anemia. It is shown that ferrihydrite nanoparticles suspension has chronic toxicity and causes morphological changes in organs (mainly in the spleen), which are characterized by accumulation of nanoparticles. Administration of phenylhydrazine induced systemic vascular damage and the formation of extramedullary hematopoietic foci, which indicated a compensatory activation in hematopoiesis in the liver and spleen. Injection of nanoparticles reduced discirculatory and necrotic changes in the kidneys.

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Authors and Affiliations

  1. Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia

    A. V. Kireeva, M. V. Loshkareva, V. P. Ladygina & S. V. Stolyar

  2. Research Institute Medical Problems of the North, Federal Research Center Krasnoyarsk Science Center, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia

    O. A. Kolenchukova & E. A. Biryukova

  3. Siberian Federal University, Krasnoyarsk, Russia

    O. A. Kolenchukova & S. V. Stolyar

Authors
  1. A. V. Kireeva
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  2. O. A. Kolenchukova
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  3. M. V. Loshkareva
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  4. E. A. Biryukova
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  5. V. P. Ladygina
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  6. S. V. Stolyar
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Corresponding author

Correspondence to A. V. Kireeva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 7, pp. 53-60, July, 2023

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Kireeva, A.V., Kolenchukova, O.A., Loshkareva, M.V. et al. Morphopathological Effect of Ferrihydrite Nanoparticles in an Experimental Model of Toxic Hemolytic Anemia. Bull Exp Biol Med 176, 42–49 (2023). https://doi.org/10.1007/s10517-023-05964-2

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  • DOI: https://doi.org/10.1007/s10517-023-05964-2

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