Skip to main content
SpringerLink
Log in

Histological Variants of Papillary Thyroid Cancer in Relation to Clinical and Morphological Parameters and Prognosis

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The correlation of histological features of papillary thyroid cancer with clinical and morphological prognostic factors and cause-specific mortality was analyzed in a case-control study within a cohort of patients from the Altai Regional Oncology Center (25 cases with lethal outcome and 64 follow-up controls). Significant variability was revealed in the histological structure of papillary thyroid cancer with the prevalence of classic (62%) and less frequent follicular (19%), tall cell (8%), and solid (7%) variants. In comparison with the classic variant, the solid variant was more often associated with male sex and large tumor size; follicular and tall cell variant was associated with more frequent metastases to regional lymph nodes; follicular and solid variants were associated with an increased proportion of cases with disease stages III-IV. The main differences reflecting the effect of histological factor on the disease outcome were associated with the solid variant of papillary thyroid cancer that was detected in 21% of lethal cases and only in 2% of control subjects. The detection of this variant can be of importance as an additional prognostic factor of the postoperative survival in papillary thyroid cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gervald VYa, Klimachev VV, Ivanov AA, Ragulina VD, Avdalyan AM, Bobrov IP, Lazarev AF. Thyroid cancer. Mezhdunarod. Nauch. Issled. Zh. 2014;(8-3):17-18. Russian.

  2. Shi X, Liu R, Basolo F, Giannini R, Shen X, Teng D, Guan H, Shan Z, Teng W, Musholt TJ, Al-Kuraya K, Fugazzola L, Colombo C, Kebebew E, Jarzab B, Czarniecka A, Bendlova B, Sykorova V, Sobrinho-Simões M, Soares P, Shong YK, Kim TY, Cheng S, Asa SL, Viola D, Elisei R, Yip L, Mian C, Vianello F, Wang Y, Zhao S, Oler G, Cerutti JM, Puxeddu E, Qu S, Wei Q, Xu H, O’Neill CJ, Sywak MS, Clifton-Bligh R, Lam AK, Riesco-Eizaguirre G, Santisteban P, Yu H, Tallini G, Holt EH, Vasko V, Xing M. Differential clinicopathological risk and prognosis of major papillary thyroid cancer variants. J. Clin. Endocrinol. Metab. 2016;101(1):264-274. https://doi.org/10.1210/jc.2015-2917

    Article  CAS  PubMed  Google Scholar 

  3. Bogolyubova AV, Abrosimov AYu, Selivanova LS, Belousov PV. Histopatological and molecular genetic characteristics of clinically aggressive variants of papillary thyroid carcinoma. Arkh. Patol. 2019;81(1):46-51. Russian. https://doi.org/10.17116/patol20198101146

  4. Nath MC, Erickson LA. Aggressive variants of papillary thyroid carcinoma: hobnail, tall cell, columnar, and solid. Adv. Anat. Pathol. 2018;25(3):172-179. https://doi.org/10.1097/PAP.0000000000000184

    Article  CAS  PubMed  Google Scholar 

  5. Bai Y, Kakudo K, Jung CK. Updates in the Pathologic Classification of Thyroid Neoplasms: a review of the World Health Organization Classification. Endocrinol. Metab. (Seoul). 2020;35(4):696-715. https://doi.org/10.3803/EnM.2020.807

    Article  PubMed  Google Scholar 

  6. Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A. Papillary thyroid cancer-aggressive variants and impact on management: a narrative review. Adv. Ther. 2020;37(7):3112-3128. https://doi.org/10.1007/s12325-020-01391-1

    Article  PubMed  PubMed Central  Google Scholar 

  7. Ho AS, Luu M, Barrios L, Chen I, Melany M, Ali N, Patio C, Chen Y, Bose S, Fan X, Mallen-St Clair J, Braunstein GD, Sacks WL, Zumsteg ZS. Incidence and mortality risk spectrum across aggressive variants of papillary thyroid carcinoma. JAMA Oncol. 2020;6(5):706-713. https://doi.org/10.1001/jamaoncol.2019.6851

    Article  PubMed  Google Scholar 

  8. Chang H, Kim SM, Chun KW, Kim BW, Lee YS, Chang HS, Hong SW, Park CS. Clinicopathologic features of solid variant papillary thyroid cancer. ANZ J. Surg. 2014;84(5):380-382. https://doi.org/10.1111/ans.12307

    Article  PubMed  Google Scholar 

  9. Ganly I, Ibrahimpasic T, Rivera M, Nixon I, Palmer F, Patel SG, Tuttle RM, Shah JP, Ghossein R. Prognostic implications of papillary thyroid carcinoma with tall-cell features. Thyroid. 2014;24(4):662-670. https://doi.org/10.1089/thy.2013.0503

    Article  CAS  PubMed  Google Scholar 

  10. Russo M, Malandrino P, Moleti M, Vermiglio F, Violi MA, Marturano I, Minaldi E, Vigneri R, Pellegriti G, Regalbuto C. Tall cell and diffuse sclerosing variants of papillary thyroid cancer: outcome and predicting value of risk stratification methods. J. Endocrinol. Invest. 2017;40(11):1235-1241. https://doi.org/10.1007/s40618-017-0688-9

    Article  CAS  PubMed  Google Scholar 

  11. Zaridze DG, Stilidi IS, Kaprin AD, Maksimovich DM. Over-diagnosis of thyroid cancer. Prak. Onkol. 2020;21(4):312-326. Russian. https://doi.org/10.31917/2104312

  12. Lazarev AF, Shoikhet YaN, Pisareva LF, Petrova VD, Terekhova SA. The factor of ionizing radiation and thyroid cancer in women in the Altai krai. Ross. Onkol. Zh. 2017;22(4):224-228. Russian. https://doi.org/10.18821/1028-9984-2017-22-4-224-228

  13. Nikiforov YE, Erickson LA, Nikiforova MN, Caudill CM, Lloyd RV. Solid variant of papillary thyroid carcinoma: incidence, clinical-pathologic characteristics, molecular analysis, and biologic behavior. Am. J. Surg. Pathol. 2001;25(12):1478-1484. https://doi.org/10.1097/00000478-200112000-00002

    Article  CAS  PubMed  Google Scholar 

  14. Ohashi R, Kawahara K, Namimatsu S, Igarashi T, Sakatani T, Sugitani I, Naito Z. Clinicopathological significance of a solid component in papillary thyroid carcinoma. Histopathology. 2017;70(5):775-781. https://doi.org/10.1111/his.13132

    Article  PubMed  Google Scholar 

  15. Vuong HG, Odate T, Duong UNP, Mochizuki K, Nakazawa T, Katoh R, Kondo T. Prognostic importance of solid variant papillary thyroid carcinoma: A systematic review and meta-analysis. Head Neck. 2018;40(7):1588-1597. https://doi.org/10.1002/hed.25123

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Federal Research Center of Fundamental and Translational Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    A. A. Ivanov, M. A. Bakarev & E. L. Lushnikova

  2. Altai Regional Oncological Center, Barnaul, Russia

    A. A. Ivanov

Authors
  1. A. A. Ivanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. A. Bakarev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. L. Lushnikova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. A. Bakarev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 11, pp. 606-613, November, 2022

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ivanov, A.A., Bakarev, M.A. & Lushnikova, E.L. Histological Variants of Papillary Thyroid Cancer in Relation to Clinical and Morphological Parameters and Prognosis. Bull Exp Biol Med 174, 647–652 (2023). https://doi.org/10.1007/s10517-023-05762-w

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-023-05762-w

Key Words

Search

Navigation