The aim of this cross-sectional observational study is to determine the contribution of polymorphisms of energy metabolism genes into metabolic disorders in Russian and Buryat adolescents with overweight and obesity. The study included 354 Russian and Buryat adolescents aged 13-18 years. Body mass index and serum levels of glucose, insulin, and leptin were measured and insulin resistance index HOMA-IR was calculated. Molecular genetic analysis for the presence of 9 loci of energy metabolism genes LEP, LEPR, POMC, FTO, and MC4R were analyzed. It was found that the risk of metabolic disorders is associated with the presence of polymorphic loci of leptin receptor gene LEPR and melanocortin receptor gene MC4R (LEPR rs1137100+LEPR rs1137101 and LEPR rs1137100+MC4R rs17782313) in Russian adolescents with overweight and obesity and polymorphisms of the gene FTO (FTO rs9939609+rs8050136) associated with fat mass and obesity in Buryat adolescents.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bairova TA, Dolgikh VV, Kolesnikova LI, Pervushina OA. Nutritciogenetics and risk factors of cardiovascular disease: associated research in Eastern Siberia populations. Acta Biomedica Scientifica. 2013;(4):87-92. Russian.
Bairova TA, Sheneman EA, Rychkova LV, Ievleva KD. FTO gene and its role in development of obesity and excessive body weight in children. Pediatriya. Zh. im. G.N.Speranksogo. 2017;96(4):186-193. Russian.
Ievleva KD, Bairova TA, Sheneman EA, Ayurova ZG, Bugun OV, Rychkova LV, Kolesnikova LI, Bal’zhieva VV, Novikova EA. The protective effect of G-allele of PPARG2 rs1801282 polymorphism against overweight and obesity in mongoloid adolescents. Zh. Med.-Biol. Issled. 2019;7(4):452-463. Russian.
Kolesnikova LI, Rychkova LV, Kolesnikov SI, Darenskaya MA, Gavrilova OA, Kravtsova OV, Grebenkina LA, Osipova EV. The evaluation of the lipid peroxidation system and antioxidant defense in adolescent boys with exogenously constitutive obesity with using the coefficient of oxidative stress. Vopr. Pitaniya. 2018;87(1):28-34. Russian.
Almeida SM, Furtado JM, Mascarenhas P, Ferraz ME, Ferreira JC, Monteiro MP, Vilanova M, Ferraz FP. Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children. Endocrine. 2018;60(3):466-478. https://doi.org/10.1007/s12020-018-1587-3
Barbian CD, Reuter CP, Renner JDP, da Silva PT, Klinger EI, Hobkirk JP, de Moura Valim AR, Burgos MS. Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents. J. Pediatr. Genet. 2020;9(1):19-26. https://doi.org/10.1055/s-0039-3399511
Bouchard C. Childhood obesity: are genetic differences involved? Am. J. Clin. Nutr. 2009;89(5):1494S-1501S. https://doi.org/10.3945/ajcn.2009.27113C
Locke AE, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518:197-206. https://doi.org/10.1038/nature14177
Mantzoros CS, Magkos F, Brinkoetter M, Sienkiewicz E, Dardeno TA, Kim SY, Hamnvik OP, Koniaris A. Leptin in human physiology and pathophysiology. Am. J. Physiol. Endocrinol. Metab. 2011;301(4):E567-E584. https://doi.org/10.1152/ajpendo.00315.2011
Mendelson MM, Marioni RE, Joehanes R, Liu C, Hedman ÅK, Aslibekyan S, Demerath EW, Guan W, Zhi D, Yao C, Huan T, Willinger C, Chen B, Courchesne P, Multhaup M, Irvin MR, Cohain A, Schadt EE, Grove ML, Bressler J, North K, Sundström J, Gustafsson S, Shah S, McRae AF, Harris SE, Gibson J, Redmond P, Corley J, Murphy L, Starr JM, Kleinbrink E, Lipovich L, Visscher PM, Wray NR, Krauss RM, Fallin D, Feinberg A, Absher DM, Fornage M, Pankow JS, Lind L, Fox C, Ingelsson E, Arnett DK, Boerwinkle E, Liang L, Levy D, Deary IJ. Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach. PLoS Med. 2017;14(1):e1002215. https://doi.org/10.1371/journal.pmed.1002215
O’Rahilly S, Farooqi IS. Genetics of obesity. Philos. Trans. R Soc. Lond. B Biol. Sci. 2006;361:1095-1105. https://doi.org/10.1098/rstb.2006.1850
Prevalence of overweight among children and adolescents. Global Health Observatory (GHO) data. World Health Organization. [URL: https://www.who.int/data/gho/data/indicators/indicator-details/GHO/prevalence-of-overweight-among-children-and-adolescents-bmi-1-standard-deviations-above-themedian-(crude-estimate)-(-)].
Razquin C, Marti A, Martinez JA. Evidences on three relevant obesogenes: MC4R, FTO and PPARγ. Approaches for personalized nutrition. Mol. Nutr. Food Res. 2011;55(1):136-149. https://doi.org/10.1002/mnfr.201000445.
Sanghera DK, Bejar C, Sharma S, Gupta R, Blackett PR. Obesity genetics and cardiometabolic health: Potential for risk prediction. Diabetes Obes. Metab. 2019;21(5):1088-1100. https://doi.org/10.1111/dom.13641
Srivastava A, Mittal B, Prakash J, Narain VS, Natu SM, Srivastava N. Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India. Oman Med. J. 2014;29(2):114-118. https://doi.org/10.5001/omj.2014.28
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 10, pp. 440-444, October, 2021
Rights and permissions
About this article
Cite this article
Ievleva, K.D., Bairova, T.A., Sheneman, E.A. et al. The Effect of Polymorphisms of Energy Metabolism Genes on Metabolic Disorders in Overweight Adolescents of Two Ethnicities. Bull Exp Biol Med 172, 430–434 (2022). https://doi.org/10.1007/s10517-022-05408-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-022-05408-3