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Histomorphological and Biochemical Analysis of Rat Model of Menopausal Skin Aging

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Bulletin of Experimental Biology and Medicine Aims and scope

The study examined the skin histomorphology and biochemistry in mature ovariectomized rats treated and not treated with estrogen. Biochemical parameters (superoxide dismutase, malondialdehyde, and hydroxyproline content) were measured in dorsal skin samples collected in 50 days after surgery. The morphology of dorsal skin was analyzed under a microscope. In ovariectomized rats, the skin levels of superoxide dismutase and hydroxyproline were significantly lower, while the superoxide dismutase content was significantly higher than in shamoperated animals (p<0.05). Estrogen therapy significantly increased the levels of superoxide dismutase and hydroxyproline and reduced superoxide dismutase level in ovariectomized rats in comparison with the corresponding parameters in untreated ovariectomized animals (p<0.05). Histomorphological analysis of the skin from non-treated ovariectomized rats revealed reduced vascularization and lower density of papillary capillaries in comparison with these parameters in sham-operated controls; estrogen treatment prevented these changes. We concluded that ovariectomized rats can be employed as a model of aging skin in menopause

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Authors and Affiliations

  1. Department of Dermatology, The Second Affiliated Hospital of BaoTou Medical College, BaoTou, China

    M. S. Ji & Y. Hao

  2. Department of Dermatology, The First Affiliated Hospital of BaoTou Medical College, BaoTou, China

    X. Y. Yang & J. Shi

Authors
  1. M. S. Ji
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  2. X. Y. Yang
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  3. Y. Hao
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  4. J. Shi
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Corresponding author

Correspondence to J. Shi.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 9, pp. 376-379, September, 2021

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Ji, M.S., Yang, X.Y., Hao, Y. et al. Histomorphological and Biochemical Analysis of Rat Model of Menopausal Skin Aging. Bull Exp Biol Med 172, 377–380 (2022). https://doi.org/10.1007/s10517-022-05396-4

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  • DOI: https://doi.org/10.1007/s10517-022-05396-4

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