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Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (Statins) Suppress Proliferation and Motility of Human CD4+ T Lymphocytes in Culture

  • BIOPHYSICS AND BIOCHEMISTRY
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Bulletin of Experimental Biology and Medicine Aims and scope

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) along with their blood lipid-lowering effect exhibit anti-inflammatory and immunomodulatory activity. We studied the effects of long-term (72-h or longer) exposure of human T lymphocytes in culture to atorvastatin and rosuvastatin (5-80 nM) on their functional activity. Treatment with statins inhibited PHA/IL-2-induced proliferation of CD4+ T lymphocytes isolated from the peripheral blood of healthy donors. This was accompanied by a decrease in the relative content of cells expressing active caspase-3. Addition of mevalonate or fetal bovine serum simultaneously with statins restored proliferative activity of cells. Culturing of CD4+ T lymphocytes with statins in the presence of IL-2 did not significantly affect the expression of chemokine receptors CCR4, CCR5, CXCR3, and CXCR4. Pretreatment with statins suppressed spontaneous and SDF-1-stimulated migration of CD4+ T lymphocytes, but little changed the content of intracellular phosphorylated protein kinases Akt, p38 and p42/44 (ERK1/2). The cellular effects of “lipophilic” atorvastatin were observed at lower concentrations compared to “hydrophilic” rosuvastatin.

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Authors and Affiliations

  1. National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia

    N. V. Radyukhina, N. Yu. Ruleva, A. Yu. Filatova & T. I. Aref’eva

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  1. N. V. Radyukhina
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  2. N. Yu. Ruleva
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  3. A. Yu. Filatova
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  4. T. I. Aref’eva
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Correspondence to N. V. Radyukhina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 8, pp. 162-167, August, 2021

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Radyukhina, N.V., Ruleva, N.Y., Filatova, A.Y. et al. Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (Statins) Suppress Proliferation and Motility of Human CD4+ T Lymphocytes in Culture. Bull Exp Biol Med 172, 137–142 (2021). https://doi.org/10.1007/s10517-021-05350-w

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  • DOI: https://doi.org/10.1007/s10517-021-05350-w

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