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Association of the NOS3 Gene Polymorphisms with the Risk of Atopic Dermatitis in Children

  • GENETICS
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied association of polymorphic markers Glu298Asp (rs1799983), C774T (rs1549758), and T786C (rs2070744) of the NOS3 gene with the risk of atopic dermatitis. It was found that T786C polymorphic marker of the NOS3 gene is associated with lower risk of erythematosquamous lichenoid atopic dermatitis. A significant association between the homozygous CC genotype in locus 786 of the NOS3 gene and the development of erythematosquamous atopic dermatitis with lichenification was revealed. The homozygous CC genotype can be considered as a risk factor of erythematosquamous atopic dermatitis with lichenification.

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Authors and Affiliations

  1. I. I. Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia

    О. А. Svitich, А. V. Kudryavtseva, Е. А. Meremianina, Е. P. Bystritskaya, V. V. Sobolev, А. I. Ryabtsev & V. V. Zverev

  2. I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

    О. А. Svitich, А. V. Kudryavtseva, Е. О. Kravtsova, А. B. Potapova & V. V. Zverev

  3. Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov, Russia

    Е. S. Slyusareva

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  1. О. А. Svitich
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  2. А. V. Kudryavtseva
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  3. Е. S. Slyusareva
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  4. Е. О. Kravtsova
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  5. Е. А. Meremianina
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  6. Е. P. Bystritskaya
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  7. V. V. Sobolev
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  8. А. I. Ryabtsev
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  9. А. B. Potapova
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  10. V. V. Zverev
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Correspondence to О. А. Svitich.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 12, pp. 778-782, December, 2020

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Svitich, О.А., Kudryavtseva, А.V., Slyusareva, Е.S. et al. Association of the NOS3 Gene Polymorphisms with the Risk of Atopic Dermatitis in Children. Bull Exp Biol Med 170, 787–790 (2021). https://doi.org/10.1007/s10517-021-05155-x

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  • DOI: https://doi.org/10.1007/s10517-021-05155-x

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