One of prospective methods for immunotherapy of tumors is modulation via immunological checkpoints, specifically, via the PD-1(CD279)/PD-L1(CD274) system. Interactions between tumor cell receptor (CD279) and the ligand on lymphocytes (CD274) leads to lymphocyte inactivation, which allows tumor escape from the immune control. Experiments on C57BL/6 mice with Lewis lung carcinoma demonstrate the possibility of reducing the expression of CD279 and CD274 on the peripheral blood and tumor tissue lymphocytes under the effects of Tussilago farfara L. polysaccharides. This phenomenon can underlie the antitumor and antimetastatic effects of these substances.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Korzh AP, Guriev AM, Belousov MV, Yusubov MS, Belyanin ML. Monosaccharide composition of the polysaccharide complex of foalfoot leaves. Byull. Sib. Med. 2011;10(5):62-65. Russian.
Ponomarev AV, Misyurin VA, Rudakova AA, Misyurin AV, Baryshnikova MA. The influence of aranoza drug formulations and “empty” liposomes on the expression of PD-L1 и PD-L2 in human melanoma cell lines. Ross. Bioter. Zh. 2017;16(2):74-81. Russian.
Manual on Experimental (Preclinical) Study of New Pharmacological Substances. Khabriev RU, ed. Moscow, 2005.
Safonova EA, Razina TG, Zueva EP, Lopatina KA, Efimova LA, Gur’ev AM, Rybalkina OYu, Khotimchenko YuS. Prospects for the Use of Plant Polysaccharides in Complex Treatment of Malignant Tumors. Eksp. Klin. Farmakol. 2012;75(9):42-47. Russian.
Protsenko SA: “Now we have an opportunity to treat patients with melanoma and see a good long-term effect”. Effekt. Farmakoterapiya. 2017;(36):4-5. Russian.
Pallis AG. A review of treatment in non-small-cell lung cancer. Eur. Oncol. Haematol. 2011.Vol. 7(3):174-178.
Shin DS, Ribas A. The evolution of checkpoint blockade as a cancer therapy: what’s here, what’s next? Curr. Opin. Immunol. 2015;33:23-35.
Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, Brahmer JR, Lawrence DP, Atkins MB, Powderly JD, Leming PD, Lipson EJ, Puzanov I, Smith DC, Taube JM, Wigginton JM, Kollia GD, Gupta A, Pardoll DM, Sosman JA, Hodi FS. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J. Clin. Oncol. 2014;32(10):1020-1030.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 3, pp. 351-355, March, 2020
Rights and permissions
About this article
Cite this article
Safonova, E.A., Lopatina, K.A., Razina, T.G. et al. Effects of Tussilago farfara L. Polysaccharides on the Expression of PD-1 (CD279) and PD-L1 (CD274) in Peripheral Blood and Tumor Tissue Lymphocytes in Mice with Lewis Lung Carcinoma. Bull Exp Biol Med 169, 378–382 (2020). https://doi.org/10.1007/s10517-020-04891-w
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-020-04891-w