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Structural Changes in the Nervous Fibers of the Colon Mucosa in Experimental Acute Colitis

  • MORPHOLOGY AND PATHOMORPHOLOGY
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Morphological, morphometric, and ultrastructural analysis of the nerve fibers in the colon mucosa was performed in C57BL/6 mice at various terms of development of acute colitis induced by dextran sodium sulphate. The nerve fibers were labeled with antibodies to pan-neuronal marker βIII-tubulin. The progression of inflammatory and ulcerative processes in the mucosa on days 3-5 was associated with hyperplasia and hypertrophy of nerve fibers that peaked on day 7 after colitis induction. Ultrastructural analysis at all terms of colitis development showed moderate degeneration of axons. Thus, hypertrophy and hyperplasia of the nervous fibers in colon mucosa in experimental acute colitis correlated with aggravation of the ulcerative process in the mucosa. These changes are determined by alteration of histoarchitectonics and regenerative processes in the mucosa.

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Authors and Affiliations

  1. Research Institute of Human Morphology, Moscow, Russia

    D. N. Khochanskiy, V. A. Mkhitarov, A. S. Sladkopevtsev, V. P. Chernikov, L. P. Mikhailova & O V. Makarova

  2. Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia

    M. T. Dobrynina & O V. Makarova

Authors
  1. D. N. Khochanskiy
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  2. V. A. Mkhitarov
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  3. A. S. Sladkopevtsev
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  4. V. P. Chernikov
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  5. L. P. Mikhailova
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  6. M. T. Dobrynina
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  7. O V. Makarova
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Corresponding author

Correspondence to D. N. Khochanskiy.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 1, pp. 113-119, January, 2020

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Khochanskiy, D.N., Mkhitarov, V.A., Sladkopevtsev, A.S. et al. Structural Changes in the Nervous Fibers of the Colon Mucosa in Experimental Acute Colitis. Bull Exp Biol Med 169, 104–109 (2020). https://doi.org/10.1007/s10517-020-04834-5

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  • DOI: https://doi.org/10.1007/s10517-020-04834-5

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