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Effects of Levofloxacin on Blood Lymphocyte Apoptosis in Patients with Pulmonary Tuberculosis: an In Vitro Study

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The effects of a fluroquinolone levofloxacin on apoptosis of peripheral blood lymphocytes from patients with infiltrative pulmonary tuberculosis were studied in vitro. It was found that levofloxacin stimulated apoptotic cell death in tuberculosis. Addition of levofloxacin to cell suspension from patients with drug-susceptible form of tuberculosis led to an increase in the number of CD95+ and AnnV+ lymphocytes. In patients with drug-resistant form of tuberculosis, only the number of apoptotic lymphocytes, but not the count of CD95+ cells increased under these conditions.

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Authors and Affiliations

  1. Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    V. A. Serebryakova, O. I. Urazova, V. V. Novitsky, A. I. Vengerovskii, T. E. Kononova, O. A. Vasil’eva & A. E. Beresneva

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  1. V. A. Serebryakova
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  2. O. I. Urazova
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  3. V. V. Novitsky
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  4. A. I. Vengerovskii
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  5. T. E. Kononova
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  6. O. A. Vasil’eva
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  7. A. E. Beresneva
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Corresponding author

Correspondence to V. A. Serebryakova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 7, pp. 123-126, July 2019

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Serebryakova, V.A., Urazova, O.I., Novitsky, V.V. et al. Effects of Levofloxacin on Blood Lymphocyte Apoptosis in Patients with Pulmonary Tuberculosis: an In Vitro Study. Bull Exp Biol Med 168, 109–112 (2019). https://doi.org/10.1007/s10517-019-04659-x

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  • DOI: https://doi.org/10.1007/s10517-019-04659-x

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