The antioxidant activity of the drug Mexidol was quantitatively measured using an objective method. The rate constant for the reaction of Mexidol with peroxyl radicals of 1,4-dioxane was measured in 1,4-dioxane solution. Mexidol was found to inhibit oxidation of 1,4-dioxane and showed good antioxidant activity comparable to that of ionol. The obtained data were interesting for studying the mechanism of action of the antioxidant in biological systems because the physicochemical properties of 1,4-dioxane are close to those of water, in which processes associated with oxidative stress occur. Measurement of the rate constant for the reaction of the inhibitor with peroxyl radical also had fundamental importance for establishing the structure—reactivity relationship in order to predict the antioxidant activity of compounds.
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References
I. F. Rusina, O. N. Karpukhin, and O. T. Kasaikina, Khim. Fiz., 32(8), 49 – 64 (2013).
M. G. Perevozkina, Khim.-farm. Zh., 40(8), 35 – 40 (2006).
N. R. Sokolova, E. V. Nikitina, L. B. Kochetova, et al., Butlerov. Soobshch., 29(1), 7 – 14 (2012).
V. N. Ushkalova and L. A. Zhuravleva, Khim.-farm. Zh., 40(11), 11 – 14 (2006).
V. A. Roginskii, Biol. Membr., 7(3), 297 – 305 (1990).
R. Amorati, A. Baschieri, and L. Valgimigli, J. Chem., 1 – 12 (2017).
L. R. Yakupova, A. V. Ivaonva, R. L. Safiullin, et al., Izv. Akad. Nauk, Ser. Khim., No. 3, 507 – 511 (2010).
L. R. Yakupova, S. G. Proskuryakov, R. L. Safiullin, et al., Butlerov. Soobshch., 28(19), 71 – 78 (2011).
R. N. Zaripov, R. L. Safiullin, V. D. Komissarov, et al., Kinet. Katal., 31(5), 1086 – 1091 (1990).
A. F. Moroni, Makromol. Chem., 105(6), 43 – 48 (1967).
G. Henrici-Olive and S. Olive, Makromol. Chem., 58(1), 188 – 194 (1962).
E. T. Denisov, Constants. Rates of Homolytic Liquid-Phase Reactions [in Russian], Nauka, Moscow (1971), pp. 51 – 64.
L. R. Yakupova, V. R. Khairullina, R. L. Safiullin, et al., Kinet. Katal., 49(3), 387 – 391 (2008).
D. Loshadkin, V. Roginsky, and E. Pliss, J. Chem. Kinet., 34(3), 162 (2002).
V. F. Tsepalov, Investigation of Synthetic and Natural Antioxidants in vitro and in vivo [in Russian], Collection of Scientific Articles, Nauka, Moscow (1992), p. 16.
E. T. Denisov and V. V. Azatyan, Inhibition of Chain Reactions [in Russian], Chernogolovka (1997), pp. 65, 68.
R. A. Nasibullina, L. R. Yakupova, and R. L. Safiullin, Kinet. Katal., 57(6), 767 – 776 (2016).
K. U. Ingold and D. A. Pratt, Chem. Rev., 114(18), 9022 – 9046 (2014).
E. S. Severin (ed.), Biochemistry [in Russian], GEOTAR-Media, Moscow (2008), p. 419.
https://journal.tinkoff.ru/list/medicines-analogues/?utm_campaign=arbitr-pulse&utm_referrer=https%3A%2F%2Fpulse. mail.ru&utm_source=pulse_mail_ru_meksidol
E. Niki, Free Radical Biol. Med., 49(4), 503 – 515 (2010).
R. Amorati, A. Baschieri, G. Morroni, et al., Chem. Eur. J., 22(23), 7924 – 7934 (2016).
Acknowledgments
The work was performed according to planned scientific research at UfIC, UFRC, RAS, on the topic “Kinetic laws and reaction mechanisms involving nitroso-oxides and peroxyl radicals,” AAAA-A20-120012090019-1.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 12, pp. 52 – 55, December, 2020.
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Semikasheva, O.V., Yakupova, L.R., Borisov, I.M. et al. Quantitative Analysis of the Antioxidant Activity of Mexidol. Pharm Chem J 54, 1282–1285 (2021). https://doi.org/10.1007/s11094-021-02356-6
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DOI: https://doi.org/10.1007/s11094-021-02356-6