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Toxic Effects of Nanostructured Silicon Dioxide on Multipotent Mesenchymal Stromal Cells

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of nanostructured silicon dioxide particles on functional activity and ultrastructure of rat multipotent mesenchymal stem cells. A dose-dependent decrease in cell adhesion to plastics and their proliferative potential, accumulation of apoptotic cells, a decrease in the electron density of cell cytoplasm due to swelling and degenerative changes of organelles, and intracellular accumulation of nanostructured of silicon dioxide particles were observed.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia

    A. P. Lykov, O. V. Poveshchenko, N. A. Bondarenko, M. A. Surovtseva, N. P. Bgatova & V. I. Konenkov

  2. Novosibirsk State Technical University, Novosibirsk, Russia

    Yu. A. Lykova

  3. E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology, Novosibirsk, Russia

    A. P. Lykov, O. V. Poveshchenko, N. A. Bondarenko & M. A. Surovtseva

Authors
  1. A. P. Lykov
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  2. Yu. A. Lykova
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  3. O. V. Poveshchenko
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  4. N. A. Bondarenko
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  5. M. A. Surovtseva
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  6. N. P. Bgatova
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  7. V. I. Konenkov
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Corresponding author

Correspondence to A. P. Lykov.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 51-54, January, 2017

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Lykov, A.P., Lykova, Y.A., Poveshchenko, O.V. et al. Toxic Effects of Nanostructured Silicon Dioxide on Multipotent Mesenchymal Stromal Cells. Bull Exp Biol Med 163, 159–162 (2017). https://doi.org/10.1007/s10517-017-3757-3

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  • DOI: https://doi.org/10.1007/s10517-017-3757-3

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