In 58 patients with coronary heart disease, the count of CD34+CD133+CD309+ endothelial progenitor cells in the blood was determined and the dynamics of the content of endothelial progenitor cells, angiogenic growth factors, and lipid parameters over 3 months of atorvastatin therapy was analyzed. Atorvastatin was administered in daily doses of 10 mg (26 patients) and 40 mg (32 patients). Control group comprised 15 healthy volunteers. In patients with coronary heart disease, the count of endothelial progenitor cells was lower by 4 times, the level of VEGF was higher by 52%, and the level of endostatin was lower by 13% than in healthy volunteers. Atorvastatin therapy significantly reduced the levels of VEGF (by 11%), C-reactive protein (by 26%), total cholesterol (by 30%), LDL cholesterol (by 35%), and triglycerides (by 18%); the levels of endostatin, MCP-1, and HDL cholesterol remained unchanged. The count of endothelial progenitor cells increased significantly by 72% irrespectively on the statin dose, but the changes were more pronounced in patients with lower initial endothelial progenitor cell counts and in patients with more drastic decrease in LDL cholesterol.
Similar content being viewed by others
References
António N, Fernandes R, Soares A, Soares F, Lopes A, Carvalheiro T, Paiva A, Pêgo G.M, Providência L.A, Gonçalves L, Ribeiro CF. Impact of prior chronic statin therapy and highintensity statin therapy at dischargeon circulating endothelial progenitor cell levels in patients with acute myocardial infarction: a prospective observational study. Eur. J. Clin. Pharmacol. 2014;70(10):1181-1193.
Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275:964-967.
Di Sciascio G, Patti G, Pasceri V, Gaspardone A, Colonna G, Montinaro A. Efficacy of atorvastatin reload in patients on chronic statin therapy undergoing percutaneous coronary intervention: results of the ARMYDA-RECAPTURE (Atorvastatin for Reduction of Myocardial Damage During Angioplasty) Randomized Trial. J. Am. Coll. Cardiol. 2009;54(6):558-565.
Eisen A, Leshem-Lev D, Yavin H, Orvin K, Mager A, Rechavia E, Bental T, Dadush O, Battler A, Kornowski R, Lev EI. Effect of High Dose Statin Pretreatment on Endothelial Progenitor Cells After Percutaneous Coronary Intervention (HIPOCRATES Study). Cardiovasc. Drugs Ther. 2015;29(2):129-135.
Friedrich EB, Walenta K, Scharlau J, Nickenig G, Werner N. CD34-/CD133+/VEGFR-2+ endothelial progenitor cell subpopulation with potent vasoregenerative capacities. Circ. Res. 2006;98(3):e20-e25.
Fu Y, Wu X, Han Q, Liang Y, He Y, Luo Y. Sulfate stabilizes the folding intermediate more than the native structure of endostatin. Arch. Biochem. Biophys. 2008;471(2):232-239.
Lin J, Kakkar V, Lu X. Impact of MCP-1 in atherosclerosis. Curr. Pharm. Des. 2014;20(28):4580-4588.
Pedersen TR, Faergeman O, Kastelein JJ, Olsson AG, Tikkanen MJ, Holme I, Larsen ML, Bendiksen FS, Lindahl C, Szarek M, Tsai J; Incremental Decrease in End Points Through Aggressive Lipid Lowering (IDEAL) Study Group. High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial. JAMA. 2005;294(19):2437-2445.
Pesaro AE, Serrano CV Jr, Katz M, Marti L, Fernandes JL, Parra PR, Campos AH. Increasing doses of simvastatin versus combined ezetimibe/simvastatin: effect on circulating endothelial progenitor cells. J. Cardiovasc. Pharmacol. Ther. 2013;18(5):447-452.
Petit I, Jin D, Rafii S. The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. Trends Immunol. 2007;28(7):299-307.
Psaltis PJ, Simari RD. Vascular wall progenitor cells in health and disease. Circ. Res. 2015;116(8):1392-1412.
Xu Q. Stem cells and transplant arteriosclerosis. Circ. Res. 2008;102(9):1011-1024.
Zampetaki A, Kirton JP, Xu Q. Vascular repair by endothelial progenitor cells. Cardiovasc. Res. 2008;78(3):413-421.
Zhang Q, Yin H, Liu P, Zhang H, She M. Essential role of HDL on endothelial progenitor cell proliferation with PI3K/Akt/cyclin D1 as the signal pathway. Exp. Biol. Med. (Maywood). 2010;235(9):1082-1092.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 23-26, January, 2017
Rights and permissions
About this article
Cite this article
Ansheles, A.A., Rvacheva, A.V. & Sergienko, I.V. Effect of Atorvastatin Therapy on the Level of CD34+CD133+CD309+ Endothelial Progenitor Cells in Patients with Coronary Heart Disease. Bull Exp Biol Med 163, 133–136 (2017). https://doi.org/10.1007/s10517-017-3753-7
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-017-3753-7