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Inhibition of Apoptosis is a Potential Way to Improving Ischemic Brain Tolerance in Combined Exposure to Hypercapnia and Hypoxia

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We compared the intensity of apoptosis in the peri-infarction area of the brain after isolated and combined exposure to hypoxia and hypercapnia prior to focal ischemic stroke modeling. Hypoxia and hypercapnia reduced the number of TUNEL-positive cells in the peri-infarction area, and their combination was most effective in comparison with effects of isolated exposures. The maximum neuroprotective effect of combined exposure to hypoxia and hypercapnia in comparison with isolated exposures was determined by inhibition of apoptosis in the peri-infarction zone.

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Authors and Affiliations

  1. Altai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia

    P. P. Tregub, V. P. Kulikov, M. E. Nagibaeva & A. S. Zabrodina

  2. Reserach Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia

    P. P. Tregub & V. P. Kulikov

  3. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

    N. A. Malinovskaya, A. B. Salmina, G. E. Gertsog & S. K. Antonova

Authors
  1. P. P. Tregub
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  2. N. A. Malinovskaya
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  3. V. P. Kulikov
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  4. A. B. Salmina
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  5. M. E. Nagibaeva
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  6. A. S. Zabrodina
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  7. G. E. Gertsog
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  8. S. K. Antonova
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Corresponding author

Correspondence to P. P. Tregub.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 5, pp. 606-609, May, 2016

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Tregub, P.P., Malinovskaya, N.A., Kulikov, V.P. et al. Inhibition of Apoptosis is a Potential Way to Improving Ischemic Brain Tolerance in Combined Exposure to Hypercapnia and Hypoxia. Bull Exp Biol Med 161, 666–669 (2016). https://doi.org/10.1007/s10517-016-3481-4

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  • DOI: https://doi.org/10.1007/s10517-016-3481-4

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