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Anticompulsive Activity of a New Pyrazolo[C]Pyridine Derivative GIZh-72 under Conditions of Unpredictable Chronic Mild Stress

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Bulletin of Experimental Biology and Medicine Aims and scope

Anticompulsive activity of a novel compound GIZh-72 (4,6-dimethyl-2-(4-chlorphenyl)-2,3-dihydro-1H-pyrazolo[4,3-C]Pyridine-3-on, chloral hydrate) in a dose of 20 mg/kg (single, subchronic, and chronic administration) in comparison with fluvoxamine (25 mg/kg) was studied in the marble burying test in the model of unpredictable chronic mild stress on BALB/c mice. GIZh-72 produced an anticompulsive effect that increased with increasing treatment duration under stress conditions in contrast to fluvoxamine that induced inversion of this effect after long-term administration. Neuroleptic activity of GIZh-72 in doses of 20 and 40 mg/kg was studied on the model of apomorphine-induced climbing in C57Bl/6 mice. In contrast to haloperidol (0.5 mg/kg), GIZh-72 exhibited no neuroleptic properties. Our results indicate that GIZh-72 holds much promise for pharmacotherapy of obsessive-compulsive disorder.

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Authors and Affiliations

  1. V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia

    N. V. Kudryashov, T. S. Kalinina, L. A. Zhmurenko & T. A. Voronina

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  1. N. V. Kudryashov
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  2. T. S. Kalinina
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  3. L. A. Zhmurenko
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  4. T. A. Voronina
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Correspondence to N. V. Kudryashov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 3, pp. 355-358, March, 2016

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Kudryashov, N.V., Kalinina, T.S., Zhmurenko, L.A. et al. Anticompulsive Activity of a New Pyrazolo[C]Pyridine Derivative GIZh-72 under Conditions of Unpredictable Chronic Mild Stress. Bull Exp Biol Med 161, 377–380 (2016). https://doi.org/10.1007/s10517-016-3418-y

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  • DOI: https://doi.org/10.1007/s10517-016-3418-y

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