Stimulation of β-adrenoreceptors with low (10–8 and 10–7 M) or high (10–6 M) doses of isoproterenol in hypokinetic rats treated with L-NAME (a non-selective blocker of NO synthases) decreased or increased myocardial contractility, respectively. In control rats, all examined doses of isoproterenol used under blockade of NO synthases inhibited myocardial contractility.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 2, pp. 169-172, February, 2016
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Zaripova, R.I., Ziyatdinova, N.I. & Zefirov, T.L. Effect of NO Synthase Blockade on Myocardial Contractility of Hypokinetic Rats during Stimulation of β-Adrenoreceptors. Bull Exp Biol Med 161, 215–217 (2016). https://doi.org/10.1007/s10517-016-3378-2
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DOI: https://doi.org/10.1007/s10517-016-3378-2