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Sirt1 Regulates p53 Stability and Expression of Its Target S100B during Long-Term Potentiation in Rat Hippocampus

  • BIOPHYSICS AND BIOCHEMISTRY
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Bulletin of Experimental Biology and Medicine Aims and scope

Induction of long-term potentiation in rat hippocampus was followed by short-term activation of transcription factor p53 and its subsequent degradation. We studied the effects of EX-527 (inhibitor of deacetylase Sirt1, a negative regulator of p53) and pifi thrin-β (inhibitor of p53-dependent transcription) on the levels of p53 protein and mRNA of its target gene S100B during long-term potentiation. Pifi thrin-β limited the increase in S100B mRNA content after tetanization, which confi rmed signifi cant contribution of p53 in the regulation of S100B during long-term potentiation. EX-527 completely prevented p53 degradation and increased S100B expression induced by tetanization. Thus, Str1 regulates stability of p53 and expression of its target gene S100B in rat hippocampus during long-term potentiation.

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Authors and Affiliations

  1. Design and Technology Institute of Computer Science, Siberian Division of the Russian Academy of Medical Science, Moscow, Russia

    P. D. Lisachev

  2. Research Institute of Molecular Biology and Biophysics, Novosibirsk, Russia

    V. O. Pustylnyak & M. B. Shtark

  3. Novosibirsk National Research State University, Novosibirsk, Russia

    V. O. Pustylnyak

Authors
  1. P. D. Lisachev
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  2. V. O. Pustylnyak
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  3. M. B. Shtark
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Corresponding author

Correspondence to M. B. Shtark.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 10, pp. 429-431, October, 2015

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Lisachev, P.D., Pustylnyak, V.O. & Shtark, M.B. Sirt1 Regulates p53 Stability and Expression of Its Target S100B during Long-Term Potentiation in Rat Hippocampus. Bull Exp Biol Med 160, 432–434 (2016). https://doi.org/10.1007/s10517-016-3189-5

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  • DOI: https://doi.org/10.1007/s10517-016-3189-5

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