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Synthesis of Some CC Chemokines and Their Receptors in the Synovium in Rheumatoid Arthritis

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the expression of some CC chemokines and their receptors in the synovium of patients with rheumatoid arthritis, osteoarthrosis, and a history of joint injury. In patients with rheumatoid arthritis, the levels mRNA for some angiogenic and proinflammatory chemokines (CCL5/RANTES, CCL11/eotaxin, CCL24/eotaxin-2, and CCL26/eotaxin-3) and their receptors (CCR1, CCR2, CCR3, CCR4, and CCR5) was elevated. mRNA expression correlated with activity, stage, and serological status of rheumatoid arthritis. Obtained data confirm the importance of CC chemokines as mediators of angiogenesis and inflammation in the synovium in rheumatoid arthritis.

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Authors and Affiliations

  1. Pasteur Saint-Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia

    D. A. Zhebrun, Areg A. Totolyan & A. P. Patrukhin

  2. V. A. Almazov Federal Heart, Blood, and Endocrinology Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia

    D. A. Zhebrun, Areg A. Totolyan, A. L. Maslyanskii, A. G. Titov & A. A. Kostareva

  3. St. Petersburg State Institute of Technology, St. Petersburg, Russia

    I. S. Gol’tseva

Authors
  1. D. A. Zhebrun
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  2. Areg A. Totolyan
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  3. A. L. Maslyanskii
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  4. A. G. Titov
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  5. A. P. Patrukhin
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  6. A. A. Kostareva
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  7. I. S. Gol’tseva
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Correspondence to D. A. Zhebrun.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 8, pp. 153-158, August, 2014

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Zhebrun, D.A., Totolyan, A.A., Maslyanskii, A.L. et al. Synthesis of Some CC Chemokines and Their Receptors in the Synovium in Rheumatoid Arthritis. Bull Exp Biol Med 158, 192–196 (2014). https://doi.org/10.1007/s10517-014-2720-9

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  • DOI: https://doi.org/10.1007/s10517-014-2720-9

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