A 5-fold decrease of the content of vitamin mixture in the ration and exclusion of vitamin E from this mixture over 4 weeks led to a significant growth delay in rats initially weighing 58.1±0.5 g, but was inessential for the growth rates of animals weighing 107.1±1.1 g. The decrease in the levels of vitamins A and B2 in the liver and of 25-hydroxyvitamin D in the plasma of younger rats was more significant, this indicating their higher sensitivity to alimentary vitamin deficit. The increase in vitamin content in the ration to 100% over 5 days led to a significant body weight increment but did not restore vitamin levels in the liver, restoring, however, plasma levels of vitamins E and 25-hydroxyvitamin D. Addition of 50% vitamin content of the vitamin mixture for controls to vitamin-deficient rations of older rats for 2 weeks improved the levels of vitamins B1 and B2, but was virtually inessential for the liver content of vitamins A and E. High dose (158-200%) vitamins in animals of both age groups repaired the deficit of all vitamins, except vitamin A, despite the fact that its doses were the highest. These results validate long-term vitamin consumption for repair of their deficit.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 5, pp. 626-629, May, 2014
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Kodentsova, V.M., Vrzhesinskaya, O.A., Beketova, N.A. et al. Efficiency of Various Vitamin Doses for Polyhypovitaminosis Correction in Rats. Bull Exp Biol Med 157, 608–611 (2014). https://doi.org/10.1007/s10517-014-2626-6
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DOI: https://doi.org/10.1007/s10517-014-2626-6