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Presence of enthesopathy in patients with primary Sjogren’s syndrome: ultrasonographic study of a local cohort

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Abstract

Background

Musculoskeletal findings in Sjögren’s syndrome are arthralgia, arthritis, myalgia, myositis, fibromyalgia, and chronic fatigue. Enthesis zones are important in the formation of pain in the musculoskeletal system. Musculoskeletal ultrasound (US) may show subclinical enthesitis in the synovial joints and in the axial skeleton before joint swelling in inflammatory diseases characterized by arthritis.

Objective

In this study, we aimed to determine the presence of enthesopathy using the Madrid sonographic enthesitis index (MASEI) in patients with primary Sjögren’s syndrome (PSS).

Patients and methods

Consecutive patients with PSS and age-matched healthy controls were included in this study. All the patients met the 2002 American College of Rheumatology/European League against Rheumatism classification criteria for PSS. The demographic characteristics of the patients were recorded. Six enthesis sites were evaluated using gray-scale and Doppler US with a linear transducer, and they were scored using the MASEI. They were assessed by the EULAR Sjögren’s syndrome disease activity index (ESSDAI).

Results

We evaluated 40 patients with PSS (average age 48.67 ± 11.23 years) and 30 healthy controls (average age 45.40 ± 8.24 years). Patients with PSS had significantly higher MASEI scores than the healthy controls. Plantar fascia, Achilles tendon, and distal patellar tendons were significantly thicker in the PSS group than in the healthy controls. The MASEI total score had a positive correlation with age. There was no correlation between MASEI total score and BMI and ESSDAI.

Conclusion

In this study, it was shown that the MASEI scores assessed by US were significantly higher in patients with PSS than in healthy controls. Plantar fascia, Achilles tendon, and distal patellar tendon were significantly thicker in the PSS group than in the healthy controls. This result suggests that PSS may be one of the causes of musculoskeletal pain that can be seen in patients with PSS. Our study was the first study to use an enthesis index ultrasonographically in patients with PSS. In addition, it is the first study to investigate the relationship between the presence of enthesopathy and disease activity by means of US.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Sakarya University Medical Faculty, Sakarya, Turkey

    Sinem Sag, Mustafa Serdar Sag, Ibrahim Tekeoglu, Ayhan Kamanlı & Kemal Nas

Authors
  1. Sinem Sag
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  2. Mustafa Serdar Sag
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  3. Ibrahim Tekeoglu
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  4. Ayhan Kamanlı
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  5. Kemal Nas
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Corresponding author

Correspondence to Sinem Sag.

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Conflict of interest

All authors declared that they have no potential conflict of interest.

Ethical statements

This study was conducted in accordance with the Declaration of Helsinki and with the approval of the local Ethics Committee.

Financial interest

We did not receive any financial support for the research and/or authorship of this article.

Informed consent

All participants provided written informed consent.

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Cite this article

Sag, S., Sag, M.S., Tekeoglu, I. et al. Presence of enthesopathy in patients with primary Sjogren’s syndrome: ultrasonographic study of a local cohort. J Med Ultrasonics 45, 121–127 (2018). https://doi.org/10.1007/s10396-017-0802-9

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  • DOI: https://doi.org/10.1007/s10396-017-0802-9

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