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Angiogenic factors: role in esophageal cancer, a brief review

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Abstract

Esophageal cancer has an aggressive behavior with rapid tumor mass growth and frequently poor prognosis; it is known as one of the most fatal types of cancer worldwide. The identification of potential molecular markers that can predict the response to treatment and the prognosis of this cancer has been subject of a vast investigation in the recent years. Among several molecules, various angiogenic factors that are linked to the tumor development, growth, and invasion, such as VEGF, HGF, angiopoietin-2, IL-6, and TGF-B1, were investigated. In this paper, the authors sought to review the role of these angiogenic factors in prognosis and hypothesize how they can be used as a treatment target.

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Author information

Authors and Affiliations

  1. Portuguese Oncology Institute, Lisbon, Portugal

    Kátia Ladeira

  2. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal

    Kátia Ladeira, Adhemar Longatto-Filho & Sandra F. Martins

  3. ICVS/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Portugal

    Kátia Ladeira, Adhemar Longatto-Filho & Sandra F. Martins

  4. Portuguese Oncology Institute, Coimbra, Portugal

    Filipa Macedo

  5. Molecular Oncology Research Center, Barretos, São Paulo, Brazil

    Adhemar Longatto-Filho

  6. Pathology Department, Hospital Braga, Braga, Portugal

    Adhemar Longatto-Filho

  7. Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil

    Adhemar Longatto-Filho

  8. Surgery Department, Coloproctology Unit, Hospital Braga, Braga, Portugal

    Sandra F. Martins

Authors
  1. Kátia Ladeira
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  2. Filipa Macedo
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  3. Adhemar Longatto-Filho
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  4. Sandra F. Martins
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Correspondence to Sandra F. Martins.

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This article does not contain any studies with human or animal subjects performed by any author(s).

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The authors have no conflicts of interest and received no financial support for this study.

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Ladeira, K., Macedo, F., Longatto-Filho, A. et al. Angiogenic factors: role in esophageal cancer, a brief review. Esophagus 15, 53–58 (2018). https://doi.org/10.1007/s10388-017-0597-1

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  • DOI: https://doi.org/10.1007/s10388-017-0597-1

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