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Two-year results of combined intravitreal ranibizumab and photodynamic therapy for retinal angiomatous proliferation

  • Clinical Investigation
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Abstract

Purpose

The aim of this study was clarify the efficacy of combination therapy of intravitreal ranibizumab (IVR) injections and photodynamic therapy (PDT) in patients with symptomatic retinal angiomatous proliferation (RAP) over 24 months.

Methods

We retrospectively reviewed 37 naïve eyes of 31 patients treated with three consecutive monthly IVR injections (0.5 mg/0.05 ml) and PDT and followed for at least 24 months.

Results

The mean logarithm of the minimum angle of resolution best-corrected visual acuity levels improved significantly (P < 0.0001) from 0.63 at baseline to 0.39 at 24 months. Geographic atrophy (GA) involving the fovea developed in nine (24 %) eyes, with a significant (P = 0.036) decrease in VA at 24 months and a high (100 %) prevalence of reticular pseudodrusen (RPD) at baseline. Complete occlusion of the retinal–retinal anastomosis seen in 35 eyes was achieved in 33 eyes at month 24. The central retinal thickness decreased significantly (P < 0.0001) from 415 to 129 μm at 24 months. The mean number of treatments during 24 months was 2.5 PDT and 5.5 IVR injections.

Conclusions

Combination therapy comprising IVR injections and PDT is generally effective in maintaining or improving VA and retinal morphology within 2 years in eyes with RAP, except for eyes with baseline RPD, which are likely to develop GA in the fovea resulting in reduced VA.

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Authors and Affiliations

  1. Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan

    Masaaki Saito, Tomohiro Iida, Mariko Kano & Kanako Itagaki

  2. Department of Ophthalmology and Visual Sciences, Akita University Graduate School of Medicine, 1-1 Niidahoncho, Akita, 010-8543, Japan

    Masaaki Saito

  3. Department of Ophthalmology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

    Tomohiro Iida

Authors
  1. Masaaki Saito
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  2. Tomohiro Iida
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  4. Kanako Itagaki
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Corresponding author

Correspondence to Masaaki Saito.

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M. Saito, None; T. Iida, None; M. Kano, None; K. Itagaki, None.

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Saito, M., Iida, T., Kano, M. et al. Two-year results of combined intravitreal ranibizumab and photodynamic therapy for retinal angiomatous proliferation. Jpn J Ophthalmol 60, 42–50 (2016). https://doi.org/10.1007/s10384-015-0417-x

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  • DOI: https://doi.org/10.1007/s10384-015-0417-x

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