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Retrospective analysis of prognostic factors in patients with duodenal adenocarcinoma

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Summary

Background

Sporadic duodenal cancer is a rare cancer entity. Therefore, the prognostic significance of clinicopathologic features is unknown. This study aimed to identify prognostic factors and compare survival with other tumour entities of the same anatomical region.

Methods

We retrospectively studied medical records of 22 patients with duodenal adenocarcinoma (DAC), who underwent resection in two German centres for pancreatic surgery (1994–2012). Mean time of follow-up was 51.3 months. Predictive factors were evaluated by log rank analysis.

Results

Whipple surgery was performed in seven cases (31.8 %), pylorus preserving pancreaticoduodenectomy in 14 cases (63.6 %) and partial duodenectomy in one case (4.5 %). R0-resection was achieved in 86.4 %. In all, 50% of our patients had nodal positive disease. Overall morbidity was 59.1 % and perioperative mortality was 9.1 %. Survival after resection was 63.6 % and 59.0 % (3- and 5-years). There was no significant survival difference between patients with DAC and ampullary cancer, but survival was longer compared with patients with pancreatic cancer.

Conclusions

Mortality seems to be high after resection of DAC. However, radical surgery should be performed due to the high number of patients with nodal positive disease. No definite prognostic factors were identified. The prognosis after resection of duodenal cancer can be compared with patients with ampullary cancer.

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Authors and Affiliations

  1. Department of Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany

    P. Téoule, F. Rückert & T. J. Wilhelm

  2. Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

    M. Distler & R. Grützmann

  3. Department of Surgery, Alfried-Krupp Krankenhaus, Essen, Germany

    M. Niedergethmann

  4. Institute of Pathology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

    T. Gaiser

Authors
  1. P. Téoule
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  2. M. Distler
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  3. M. Niedergethmann
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  4. T. Gaiser
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  5. F. Rückert
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  6. R. Grützmann
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  7. T. J. Wilhelm
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Corresponding author

Correspondence to P. Téoule.

Additional information

P. Téoule and M. Distler contributed equally.

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Téoule, P., Distler, M., Niedergethmann, M. et al. Retrospective analysis of prognostic factors in patients with duodenal adenocarcinoma. Eur Surg 48, 228–234 (2016). https://doi.org/10.1007/s10353-015-0374-0

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  • DOI: https://doi.org/10.1007/s10353-015-0374-0

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