Summary
Background
Thymidine kinase 1 was regarded as a good serological marker for cell proliferation. In recent years, the role of thymidine kinase 1 in occurrence, development, and prognosis of tumors gradually attracted people’s attention and had been regarded as a sensitive indicator of tumor. The aim of the present study was to investigate the clinical value of detection of serum thymidine kinase 1 in colorectal carcinoma.
Methods
In this study, the level of serum thymidine kinase 1 in 150 patients with colorectal carcinoma, 36 patients with benign colorectal diseases, and 40 normal controls was determined by a chemiluminescence dot blot assay.
Results
The level of serum thymidine kinase 1 in patients with colorectal carcinoma was much higher than that in patients with benign colorectal diseases and normal controls (P < 0.01), but there was no significant difference between the level of serum thymidine kinase 1 in patients with benign colorectal diseases and that in normal controls (P > 0.05). The level of serum thymidine kinase 1 declined significantly 1 month after operation. The positive rate of serum thymidine kinase 1 in patients with colorectal carcinoma was much higher than other digestive tumor markers [carcinoembryonic antigen (CEA), carbohydrate antigen (CA-199, CA-724)].
Conclusions
The detection of serum thymidine kinase 1 might have high clinical value in auxiliary diagnosis, curative effect monitoring, and prognosis judgment of colorectal carcinoma.
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Acknowledgments
This research was supported by grants from the Key Scientific and Technological Project of Henan Province in China (No. 132102310061).
Ethical standards statement
In this study, all procedures followed were in accordance with the ethical standards of the Institutional Ethic Committee of Henan Cancer Hospital on human experimentation. The experimental protocol and informed consent procedure were in compliance with the Helsinki Declaration of 1975, as revised in 2008 (5).
Statement of informed consent
In this study, informed consent was obtained from all patients for being included in the study. All persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study have been omitted.
Conflict of interest
Yongchao Zhang, Jiaxiang Wang, Jianguo Xie, Donghua Yang, Guangsen Han, Qiang Fu, and Yonglei Zhang declare that they have no conflict of interest.
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Zhang, Y., Wang, J., Xie, J. et al. The assay and clinical significance of serum thymidine kinase 1 in patients with colorectal carcinoma. Eur Surg 47, 248–253 (2015). https://doi.org/10.1007/s10353-015-0342-8
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DOI: https://doi.org/10.1007/s10353-015-0342-8