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Autonomic function and brain volume

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Abstract

Objective

The aim of this study is to review the evidence on the role of the autonomic nervous system as a determinant of brain volume. Brain volume measures have gained increasing attention given its biological importance, particularly as a measurement of neurodegeneration.

Methods

Using an integrative approach, we reviewed publications addressing the anatomical and physiological characteristics of brain autonomic innervation focusing on evidence from diverse clinical populations with respect to brain volume.

Results

Multiple mechanisms contribute to changes in brain volume. Autonomic influence on cerebral blood volume is of significant interest.

Conclusion

We suggest a role for the autonomic innervation of brain vessels in fluctuations of cerebral blood volume. Further investigation in several clinical populations including multiple sclerosis is warranted to understand the specific role of parenchyma versus blood vessels changes on final brain volume.

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Authors and Affiliations

  1. Department of Clinical Neurological Sciences, London Health Sciences Centre, University Hospital, London, ON, Canada

    Juan M. Racosta & Kurt Kimpinski

  2. Schulich School of Medicine and Dentistry, Western University, 339 Windermere Road, London, ON, Canada

    Juan M. Racosta & Kurt Kimpinski

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  1. Juan M. Racosta
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Correspondence to Juan M. Racosta.

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Racosta, J.M., Kimpinski, K. Autonomic function and brain volume. Clin Auton Res 26, 377–383 (2016). https://doi.org/10.1007/s10286-016-0380-8

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