Abstract
Kawasaki disease (KD) arises due to the acute inflammation and immune system dysfunction. This study investigated the relationship between the serum level of IL-35 and coronary artery lesions (CALs) in patients with KD. We obtained blood samples from 90 children with KD before intravenous immunoglobulin therapy. Levels of IL-35, IL-6, IL-17A, IL-10, MCP-1 and VEGF were measured in 190 cases, including 4 groups: KD with coronary arterial lesions (n = 46), KD without coronary arteries lesions (n = 44), febrile control group (FC, n = 40) and the normal control group (NC, n = 60). White blood cell counts (WBC), red blood cell counts (RBC), hemoglobin, platelet, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and procalcitonin were tested in all subjects. Levels of IL-35, RBC and hemoglobin significantly decreased, and IL-6, IL-17A, IL-10, MCP-1 and VEGF were significantly elevated in the KD group compared with febrile and control groups. IL-35 serum level even decreased, and ESR, IL-6, MCP-1 and VEGF increased in the KD patients with CALs. Serum levels of IL-35 in KD patients were negatively associated with WBC, CRP, IL-6, IL-17A, IL-10, MCP-1 and VEGF in children with KD. IL-35 may have the effect on inhibiting inflammatory process in KD and further preventing KD patients from coronary artery lesion.
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Change history
31 August 2018
The article Association between IL‑35 and coronary arterial lesions in children with Kawasaki disease, written by Ya Su, Siqi Feng, Li Luo, Ruixi Liu and Qijian Yi, was originally published electronically on the publisher’s internet portal (currently SpringerLink) on 27 July 2018 with open access.
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This work was supported by National Natural Science Foundation of China under Grant No. 81500273.
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All authors have no actual or potential conflicts of interest with other people or organizations to this work.
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The study protocol was approved by the Ethics Committee of Children’s Hospital of Chongqing Medicine University, and written informed consent forms were obtained from the parents of all subjects.
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The original version of this article was revised: due to a retrospective Open Access cancellation.
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Su, Y., Feng, S., Luo, L. et al. Association between IL-35 and coronary arterial lesions in children with Kawasaki disease. Clin Exp Med 19, 87–92 (2019). https://doi.org/10.1007/s10238-018-0513-6
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DOI: https://doi.org/10.1007/s10238-018-0513-6