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Gap Detection Deficits in Chinchillas with Selective Carboplatin-Induced Inner Hair Cell Loss

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Abstract

Temporal resolution is essential for processing complex auditory information such as speech. In hearing impaired persons, temporal resolution, often assessed by detection of brief gaps in continuous sound stimuli, is typically poorer than in individuals with normal hearing. At low stimulus presentation levels, hearing impaired individuals perform poorly but the deficits are greatly reduced when the sensation level of the stimuli are adjusted to match their normal hearing peers. In the present study, we evaluated the effect of selective inner hair cell loss on gap detection in chinchillas treated with carboplatin, an anticancer drug that selectively damages inner hair cells and afferents in this species. Treatment with carboplatin-induced inner hair cell loss of ~ 70 % but had little effect on audiometric thresholds in quiet and produced no evidence of outer hair cell loss. In contrast, selective inner hair cell loss had a significant effect on gap detection ability across a wide range of presentation levels. These results suggest that gap detection tasks are more sensitive to inner hair cell pathology than audiometric thresholds.

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Abbreviations

ABR:

Auditory brainstem response

CANS:

Central auditory nervous system

BBN:

Broadband noise

dB:

Decibel

IHC:

Inner hair cell

OHC:

Outer hair cell

SD:

Standard deviation

SEM:

Standard error of the mean

SPL:

Sound pressure level

SDH:

Succinate dehydrogenase

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Acknowledgements

Research reported in this publication was supported by the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health under award numbers R03DC011612 and R01DC014088.

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Authors and Affiliations

  1. School of Behavioral and Brain Sciences, Callier Center for Communication Disorders, The University of Texas at Dallas, 1966 Inwood Road, Dallas, TX, 75235, USA

    Edward Lobarinas

  2. Center for Hearing and Deafness, The State University of New York at Buffalo, Buffalo, NY, USA

    Richard Salvi & Dalian Ding

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  1. Edward Lobarinas
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  2. Richard Salvi
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  3. Dalian Ding
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EL and DD performed data collection, analysis, and all authors contributed to writing the manuscript.

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Correspondence to Edward Lobarinas.

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Lobarinas, E., Salvi, R. & Ding, D. Gap Detection Deficits in Chinchillas with Selective Carboplatin-Induced Inner Hair Cell Loss. JARO 21, 475–483 (2020). https://doi.org/10.1007/s10162-020-00744-5

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