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Significance of urinary liver-type fatty acid-binding protein in patients with normal renal function after undergoing intestinal urinary diversion: a preliminary study

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Abstract

Background

Liver-type fatty acid-binding protein (L-FABP) in urine is one of the early diagnostic biomarkers for acute and chronic kidney injuries. Although this protein is also identified in the intestine, there is no verified reference value for patients with intestinal urinary diversion (UD). The aim of the present study was to measure L-FABP values in such patients and compare them with the results for patients without UD.

Methods

Spot urine specimens were collected from 41 patients with UD and 50 subjects without UD with estimated glomerular filtration rates of over 60 ml/min/1.73 m2, and the L-FABP values were measured. The normal upper cutoff value in healthy subjects without UD is considered to be 7.24 μg/g Cr. First, the median values of the two groups were compared. Next, the subjects with negative proteinuria and without comorbidities associated with renal function were further selected and the median values of the groups were compared.

Results

The mean age was significantly higher in the UD group. The types of UD were ileal conduit (38 patients) and ileal neobladder (three patients). The median L-FABP value in the UD group was significantly higher than that in the non-diversion group (89.1 μg/g Cr vs. 2.0 μg/g Cr, p < 0.0001). After adjustment for their backgrounds, the median value remained higher in the UD group.

Conclusions

L-FABP values in subjects with UD are higher than in those without UD. By this result, to develop a reference value in patients with intestinal UD population, further studies are required.

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Acknowledgements

The authors thank Mr. Kim Barrymore for the correction of English in this manuscript.

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Authors and Affiliations

  1. Department of Urology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, 060-8543, Japan

    Takeshi Maehana, Koji Ichihara, Kohei Hashimoto, Toshiaki Tanaka & Naoya Masumori

  2. Department of Infection Control and Laboratory Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

    Satoshi Takahashi

  3. Department of Clinical Laboratory Science, School of Medical Technology, Health Sciences University of Hokkaido, Sapporo, Japan

    Yusuke Takahashi

Authors
  1. Takeshi Maehana
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  2. Koji Ichihara
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  3. Satoshi Takahashi
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  4. Yusuke Takahashi
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  5. Kohei Hashimoto
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  6. Toshiaki Tanaka
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  7. Naoya Masumori
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Correspondence to Takeshi Maehana.

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The authors have declared that no conflict of interest exists.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee at which the studies were conducted (approval no. 272-96) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Since this was an observational, but not prospective, intervention study, the Ethics Committee provided a waiver of written informed consent. We announced the commencement of this study on our website (http://web.sapmed.ac.jp/la/) with the proviso that the patients who participated in this study could withdraw later.

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Maehana, T., Ichihara, K., Takahashi, S. et al. Significance of urinary liver-type fatty acid-binding protein in patients with normal renal function after undergoing intestinal urinary diversion: a preliminary study. Clin Exp Nephrol 25, 1151–1157 (2021). https://doi.org/10.1007/s10157-021-02088-7

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  • DOI: https://doi.org/10.1007/s10157-021-02088-7

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