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Topical hemostatic agents in neurosurgery, a comprehensive review: 15 years update

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Abstract

Hemostasis in neurosurgery is of utmost importance. Bleeding management is one of the crucial steps of each neurosurgical procedure. Several strategies, namely thermal, mechanical, electric, and chemical, have been advocated to face blood loss within the surgical field. Over time, countless hemostatic agents and devices have been proposed. Furthermore, the ever-growing recent technological innovation has made available several novel and interesting tools. Pursuant to their impact on surgical practice, we perceived the imperative to update our previous disclosure paper. Therefore, we reviewed the literature and analyzed technical data sheets of each product in order to provide an updated and comprehensive overview in regard to chemical properties, mechanisms of action, use, complications, tricks, and pitfalls of topical hemostatic agents.

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Author notes

  1. C. Schonauer and C. Mastantuoni contributed equally to this work.

Authors and Affiliations

  1. Division of Neurosurgery, Santa Maria Delle Grazie Hospital, AslNa2Nord, 80078, Pozzuoli, Italy

    C. Schonauer & R. de Falco

  2. Department of Neuroscience and Reproductive and Dental Sciences, Division of Neurosurgery, Università Degli Studi Di Napoli Federico II, Via Pansini 5, 80131, Naples, Italy

    C. Mastantuoni, T. Somma & P. Cappabianca

  3. Department of Neurosurgery, Faculty of Medicine, Geneva University Hospital, 6, Rue Gabrielle Perret Gentil, 1211, Geneva, Switzerland

    E. Tessitore

Authors
  1. C. Schonauer
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  2. C. Mastantuoni
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  3. T. Somma
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  4. R. de Falco
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  5. P. Cappabianca
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Contributions

1. Claudio Schonauer.

Research project: Conception, Organization, and Execution; Manuscript: Writing of the first draft, Review and Critique.

2. Ciro Mastantuoni

Research project: Conception, Organization, and Execution; Manuscript: Writing of the first draft, Review and Critique.

3. Teresa Somma

Manuscript: Review and Critique.

4. Raffaele de Falco

Manuscript: Review and Critique.

5. Paolo Cappabianca

Manuscript: Review and Critique.

6. Enrico Tessitore

Research project: Conception, Organization, and Execution; Manuscript: Review and Critique.

Corresponding author

Correspondence to C. Mastantuoni.

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Schonauer, C., Mastantuoni, C., Somma, T. et al. Topical hemostatic agents in neurosurgery, a comprehensive review: 15 years update. Neurosurg Rev 45, 1217–1232 (2022). https://doi.org/10.1007/s10143-021-01684-1

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  • DOI: https://doi.org/10.1007/s10143-021-01684-1

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