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Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma

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Abstract

Traditional cancer treatments have disadvantages of large trauma area and toxic side effects while killing cancer cells. Peptide-targeted sonodynamic therapy (SDT) can effectively improve specificity of cancer treatment and overcome the problem of low tissue penetration depth caused by a photo-driven therapy. Herein, we developed a porphyrin-based sonosensitizer with a water-soluble polymer as a biological carrier and a cRGD peptide for tumor targeting, which constituted a nano sonosensitizer (T-cRGD NPs) for fluorescence imaging-guided sonodynamic therapy. A comparable sonosensitizer (T-PEG NPs) without the targeting unit was also prepared for illustration of therapeutic performance. Attribute to the role of peptide targeting, T-cRGD NPs can accumulate and enter tumor cells for fluorescence imaging and show a superior SDT effect than T-PEG NPs in vitro. The imaging in vivo reveals that T-cRGD NPs can enrich in tumor tissues within 14 h with a good biocompatibility.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (Nos. 21873110 and 61720106014) and the Instrument Developing Project of the Chinese Academy of Sciences (No. YJKYYQ20170015).

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Authors and Affiliations

  1. Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China

    Mei-Yu Jiang, Jia-Sheng Wu, Wei-Min Liu, Hao-Hui Ren, Xin Wang & Peng-Fei Wang

  2. School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, China

    Mei-Yu Jiang, Wei-Min Liu, Xin Wang & Peng-Fei Wang

Authors
  1. Mei-Yu Jiang
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  2. Jia-Sheng Wu
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  3. Wei-Min Liu
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  4. Hao-Hui Ren
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  5. Xin Wang
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  6. Peng-Fei Wang
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Corresponding authors

Correspondence to Jia-Sheng Wu or Peng-Fei Wang.

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The authors declare no competing financial interest.

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Jiang, MY., Wu, JS., Liu, WM. et al. Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma. Chin J Polym Sci 40, 1120–1128 (2022). https://doi.org/10.1007/s10118-022-2795-0

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  • DOI: https://doi.org/10.1007/s10118-022-2795-0

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