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Assessment of tissue pathology using optical polarimetry

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Abstract

Optical polarimetry have been extensively used for the non-invasive assessment of biological tissues. However, the knowledge regarding differences in polarimetric signatures of different tissue pathologies is very scattered, confounding the deduction of a global trend of the polarimetric variables for healthy and pathological tissues. The purpose of this study was to bridge this gap. We conducted a rigorous online survey to collect all published studies that report the two most common polarimetric variables (i.e., depolarization and retardance) for any type of tissue pathology. A total of 101 studies describing the polarimetric assessment of tissues were collected, wherein 253 (i.e., nhuman = 149, nanimal = 104) different type of tissues were optically characterized. Most tissue samples (172/253) were investigated in ex vivo settings. The data showed 32 different types of tissues pathologies, where the most common pathology was cancer and its subtypes. The skin tissues were the most frequently explored tissues, followed by tissue samples from breast, colon, liver, and cervix. Although differences in polarimetric signatures of different tissue pathologies were summarized from the included studies, generalization of the results was hindered by the presentation of polarimetric data in a non-uniform format. The analyses presented in this study may provide an important reference for future polarimetric studies that conduct optical assessment of tissues at greater depth, particularly in the context of optical biopsy/digital staining.

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Data availability

Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

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Authors and Affiliations

  1. DHQ and Teaching Hospital, Sahiwal, Pakistan

    Zahra Ali, Tariq Mahmood & Ayesha Shahzad

  2. Department of Physics, Islamia College Peshawar, Khyber Pakhtunkhwa, Pakistan

    Muaz Iqbal

  3. Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar, Pakistan

    Iftikhar Ahmad

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  1. Zahra Ali
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  2. Tariq Mahmood
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  3. Ayesha Shahzad
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  4. Muaz Iqbal
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  5. Iftikhar Ahmad
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Correspondence to Iftikhar Ahmad.

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Ali, Z., Mahmood, T., Shahzad, A. et al. Assessment of tissue pathology using optical polarimetry. Lasers Med Sci 37, 1907–1919 (2022). https://doi.org/10.1007/s10103-021-03450-7

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