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Plasmonic hyperthermia or radiofrequency electric field hyperthermia of cancerous cells through green-synthesized curcumin-coated gold nanoparticles

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Abstract

Nanoparticle-mediated hyperthermia is one of the prominent adjuvant therapies which has been faced by many problematic challenges such as efficiency and safety. To compare the nanoparticle-mediated photothermal therapy and radiofrequency electric field hyperthermia, green-synthesized curcumin-coated gold nanoparticles (Cur@AuNPs) were applied in an in vitro study. Using recently published methodologies, each step of the study was performed. Through green chemistry, curcumin was applied as both a reducing and a capping agent in the gold nanoparticle synthesis process. Various techniques were applied for the characterization of the synthesized nanoparticles. The heating rate of Cur@AuNPs in the presence of RFEF or laser irradiation was recorded by using a non-contact thermometer. The cellular uptake of the Cur@AuNPs was studied by ICP-AES. The cellular viability and apoptosis rate of different treatment were measured to investigate the effect of two different nano-hyperthermia techniques on the murine colorectal cancer cell line. The average size of Cur@AuNPs was 7.2 ± 3.3 nm. The stability of the gold nanoparticles in the phosphate buffer saline with and without fetal bovine serum was verified by UV–Vis spectroscopy. FTIR, UV–Vis spectroscopy, and TEM indicate that the stability is a result of phenolic coating on the surface of nanoparticles. Cur@AuNPs can absorb both light and radiofrequency electric field exposure in a way that could kill cancerous cells in a significant number (30% in 64 μg/ml concentration). Green-synthesized Cur@AuNPs could induce apoptosis cell death in photothermal therapy and radiofrequency electric field hyperthermia.

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Funding

The current research has been supported by the Iran University of Medical Sciences (IUMS) under grant number 99–3-68–18954.

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Authors and Affiliations

  1. Department of Medical Physics, Lorestan University of Medical Sciences, Khorramabad, Iran

    Abbas Rezaeian

  2. Radiation Biology Research Center, Iran University of Medical Sciences (IUMS), 14003391769, Tehran, Iran

    Seyed Mohammad Amini

  3. Medical Nanotechnology Department, School of Advanced Technologies in Medicine, Tran University of Medical Sciences (IUMS), Tehran, Iran

    Mohammad Reza H. Najafabadi

  4. Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada

    Zohreh Jomeh Farsangi

  5. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Hadi Samadian

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  1. Abbas Rezaeian
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  2. Seyed Mohammad Amini
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  3. Mohammad Reza H. Najafabadi
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  4. Zohreh Jomeh Farsangi
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  5. Hadi Samadian
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Correspondence to Seyed Mohammad Amini.

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Rezaeian, A., Amini, S.M., Najafabadi, M.R.H. et al. Plasmonic hyperthermia or radiofrequency electric field hyperthermia of cancerous cells through green-synthesized curcumin-coated gold nanoparticles. Lasers Med Sci 37, 1333–1341 (2022). https://doi.org/10.1007/s10103-021-03399-7

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  • DOI: https://doi.org/10.1007/s10103-021-03399-7

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